【摘要】 目的 探讨在冻融胚胎周期中应用低分子肝素(LMWH)改善子宫动脉血流阻力对多囊卵巢综合征(PCOS)患者妊娠结局的影响。方法 83例PCOS患者依据冻融胚胎移植(FET)期间是否使用LMWH分为对照组(40例)与观察组(43例)。分析两组子宫内膜血流相关指标[搏动指数(PI)、阻力指数(RI)、收缩末期与舒张末期血流速度比值(S/D)]、妊娠结局及不良反应。结果 治疗后，观察组子宫内膜血流PI、RI及S/D低于对照组，胚胎种植率66.23%高于对照组48.61%,差异有统计学意义(P<0.05);早期流产率5.71%低于对照组的28.57%(P<0.05);两组临床妊娠率及不良反应发生率比较，差异无统计学意义(P>0.05)。结论 在冻融胚胎周期中应用LMWH治疗，可改善PCOS患者子宫动脉血流情况，提高胚胎种植率，改善患者妊娠结局。更多还原

【Abstract】 Objective To investigate the effects of low-molecular-weight heparin(LMWH) applied to improve uterine arterial resistance to blood flow in frozen-thawed embryo cycles on pregnancy outcomes in patients with polycystic ovary syndrome(PCOS). Methods 83 patients with PCOS were divided into a control group(40 cases) and an observation group(43 cases) based on whether LMWH was used during freeze-thaw embryo transfer(FET). Endometrial blood flow-related indexes of pulsatility index(PI), resistance index(RI), ratio of end-systolic to end-diastolic blood flow velocity(S/D), pregnancy outcome and adverse reactions were analyzed in the two groups. Results After treatment, the endometrial blood flow PI, RI and S/D of the observation group were lower than those of the control group, and the embryo implantation rate as 66.23% was higher than that of the control group as 48.61%, with a statistically significant difference(P<0.05); the rate of early miscarriage was lower than that of the control group as 5.71%, which was lower than that of the control group as 28.57%(P<0.05); the comparison of the rates of clinical pregnancy and the incidence of adverse reactions of the two groups did not have a statistically significant difference(P>0.05). Conclusion Application of LMWH therapy in frozen-thawed embryo cycles improves uterine arterial blood flow, increases embryo implantation rates, and improves pregnancy outcomes in patients with PCOS.更多还原