【摘要】 目的 ：评价6种口腔护理方法对于癌症患儿化疗后口腔黏膜炎防治效果，为防治癌症患儿化疗后口腔黏膜炎及提升其远期生存质量提供依据。方法 ：检索中英文数据库中关于防治癌症患儿化疗后口腔黏膜炎的随机对照试验，检索时间为建库至2023年5月31日，由2名研究者独立进行检索及资料提取。采用ADDIS1.16.1软件进行网状Meta分析。结果 ：共纳入文献21篇。Meta分析结果显示，使用醋酸氯己定溶液漱口为降低癌症患儿化疗后口腔黏膜炎发生率的最佳选择；低剂量激光疗法对于降低癌症患儿化疗后口腔黏膜炎发生率、严重口腔黏膜炎发生率，缩短口腔黏膜炎愈合时间三者综合效果最好；涂抹蜂蜜在缩短癌症患儿化疗后口腔黏膜炎愈合时间方面效果最优。结论 ：不同的口腔护理方法在防治口腔黏膜炎上各具优势，临床上应针对癌症患儿化疗后口腔黏膜炎的不同分期有针对性地选择防治方案，以期有效地预防和快速地治愈其口腔黏膜炎。更多还原

【Abstract】 Objective: To evaluate the effects of six different oral care methods on the prevention and treatment of oral mucositis after chemotherapy in children with cancer, and to provide a basis for the prevention and treatment of oral mucositis after chemotherapy and to improve the long-term quality of life of children with cancer. Methods: Randomized controlled trials on the prevention and treatment of oral mucositis after chemotherapy in children with cancer were searched in Chinese and English databases from the time of establishment to May 31, 2023, and were independently searched and data extracted by two researchers. Network Meta-analysis was performed using ADDIS1.16.1 software. Results: A total of 21 articles were included. The results of Meta-analysis showed that chlorhexidine solution was the best choice to reduce the incidence of oral mucositis after chemotherapy in children with cancer. Low-dose laser therapy has the best effect on reducing the incidence of oral mucositis, the incidence of severe oral mucositis and the healing time of oral mucositis after chemotherapy in children with cancer. Honey is the most effective in shortening the healing time of oral mucositis after chemotherapy in children with cancer. Conclusion: Different oral care methods have their own advantages in the prevention and treatment of oral mucositis.In clinical practice, it is necessary to select the prevention and treatment plan according to the different stages of oral mucositis after chemotherapy in children with cancer, so as to effectively prevent and quickly cure the oral mucositis.更多还原