【摘要】 目的 了解泌尿生殖系统疾病就诊人群解脲脲原体（Ureaplasma urealyticum）感染、分布特点及耐药现状，为解脲脲原体的预防和治疗提供数据支持。方法 随机收集2022年2月—2023年4月四川省人民医院泌尿生殖系统疾病就诊人群尿道或生殖道分泌物样本，采用实时荧光定量PCR方法检测解脲脲原体核酸，同时检测沙眼衣原体核酸，并对解脲脲原体阳性标本进行药敏试验。结果 收集到符合条件的222例患者样本中，检出55例解脲脲原体阳性，阳性率24.77%；检出1例沙眼衣原体阳性，阳性率0.45%。女性泌尿生殖道感染者中解脲脲原体阳性率比男性高，分别为40.98%和18.63%;30～34岁年龄组检出率最高（29.87%）,20～24岁年龄组检出率最低（14.29%）。药敏试验显示，解脲脲原体对四环素类抗菌药物耐药率最低，0.61%；其次为大环内酯类抗菌药物，平均耐药率不超过20%；而对氟喹诺酮类药物的耐药率最高，达49.55%。结论 解脲脲原体感染率明显高于沙眼衣原体，对解脲脲原体病例可选用四环素类和大环内酯类抗菌药物。更多还原

【Abstract】 Objective To understand the current situation of Ureaplasma urealyticum infection,distribution and drug resistance in the population with genitourinary diseases,to provide support to the prevention and treatment of Ureaplasma urealyticum infection. Methods The samples of urethral or genital tract secretions were randomly collected from the People’s Hospital of Sichuan Province from February 2022 to April 2023,Real-time fluorescence quantitative PCR was used to detect Ureaplasma urealyticum,as well as Chlamydia trachomatis was detected. Drug susceptibility test was performed on Ureaplasma urealyticum positive samples. Results Of the 222 patient samples collected,55 cases were positive for Ureaplasma urealyticum,with a positive rate of 24.77%,1 case was positive for Chlamydia trachomatis,with a positive rate of 0.45%. The positive rate of Ureaplasma urealyticum in female with genitourinary infections was higher than that in male,which was 40.98% and 18.63%,respectively. The positive rate was highest in the age 30-34 years(29.87%),lowest in the age 20-24 years(14.29%). Drug susceptibility testing showed that Ureaplasma urealyticum had the lowest resistance rate to tetracycline(0.61%),followed by macrolide with an average resistance rate of not more than 20%,the highest resistance rate was to fluoroquinolones(49.55%).Conclusion The infection rate of Ureaplasma urealyticum was significantly higher than that of Chlamydia trachomatis,tetracyclines and macrolides could be used in Ureaplasma urealyticum infection cases.更多还原