【摘要】 目的 分析2010—2021年广州市初治HIV感染者糖脂代谢异常患病率的变化，探讨性别、年龄、时期、队列因素的影响。方法 基于广州市第八人民医院2010—2021年16 454例初治HIV感染者数据，采用Joinpoint回归模型分析糖代谢异常、甘油三酯代谢异常、胆固醇代谢异常的患病率变化趋势，采用年龄-时期-队列模型分析患病率变化的影响因素。结果 16 454例初治HIV感染者中，平均年龄（36.78±12.07）岁，男性13 783例（83.8%）。2010—2021年期间初治HIV感染者糖代谢异常（AAPC=-2.4%,95%CI:-5.31%～0.50%,P=0.103）、甘油三酯代谢异常（APC=AAPC=-4.13%,95%CI:-7.59%～-0.54%,P=0.029）、胆固醇代谢异常（APC=AAPC=-13.47%,95%CI:-16.03%～-10.84%,P<0.001）患病率整体均呈下降趋势，女性脂代谢异常患病率高于男性。年龄-时期-队列模型结果显示，糖代谢异常、甘油三酯代谢异常的患病率在40～50岁最高，胆固醇代谢异常患病率随年龄增大逐渐下降；糖脂代谢异常的患病率随时期整体呈下降趋势；较早出生队列的人群糖脂代谢异常的患病率较高。结论 近年来初治HIV感染者糖脂代谢异常负担整体降低，但仍应加强对糖代谢异常的防控。女性、中老年群体、较早的感染者是糖脂代谢异常的高危群体。更多还原

【Abstract】 Objective To analyze the changes in the prevalence of abnormal glucose and lipid metabolism among newly treated HIV-infected patients in Guangzhou from 2010 to 2021,and explore the influence of gender,age,period,and cohort factors.MethodsBased on the treatment data of 16 454 newly treated HIV-infected patients at Guangzhou Eighth People’s Hospital from 2010 to 2021,the trends in the prevalence of abnormal glucose,triglyceride,and cholesterol metabolism were analyzed by using Joinpoint regression,and the influencing factors of prevalence change were analyzed by using age-period-cohort model.ResultsAmong the 16 454 newly treated HIV-infected patients,the mean age was(36.78±12.07)years old,and 13 783(83.8%)were males.From 2010 to 2021,the prevalence of abnormal glucose metabolism(AAPC=-2.4%,95%CI:-5.31%-0.50%,P=0.103),abnormal triglyceride metabolism(APC=AAPC=-4.13%,95%CI:-7.59%--0.54%,P=0.029),and abnormal cholesterol metabolism(APC=AAPC=-13.47%,95%CI:-16.03%--10.84%,P<0.001)showed a downward trend.The prevalence of abnormal lipid metabolism in females was higher than that in males.The results of the age-period-cohort model showed that the prevalence of abnormal glucose metabolism and triglyceride metabolism was highest in the age of 40-50 years,the prevalence of abnormal cholesterol metabolism gradually declined with age;the prevalence of abnormal glucose and lipid metabolism showed an overall decreasing trend with the period;and the prevalence of abnormal glucose and lipid metabolism was higher in the population of the earlier birth cohort.ConclusionsThe overall burden of abnormal glucose and lipid metabolism among newly treated HIV-infected patients has decreased in recent years.However,there is a need to enhance the prevention and control measures for abnormal glucose metabolism.Females,middle-aged and older groups,and earlier infected individuals are at high risk for abnormal glucose and lipid metabolism.更多还原