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骨髓增生异常综合征在斑马鱼中的研究进展
Research progress of myelodysplastic syndrome in zebrafish
【摘要】 骨髓增生异常综合征(myelodysplastic syndrome,MDS)是一种常见的血液疾病,其发病率呈现逐年上升的趋势。斑马鱼作为一种生物医学研究的模式生物,广泛应用于各类疾病的研究中。本文关注了近年来血液疾病在斑马鱼中的研究,MDS在小鼠、大鼠和斑马鱼中的研究及动物模型的应用,揭示了斑马鱼模型在其中发挥的重要作用。
【Abstract】 Myelodysplastic syndrome(MDS) is a prevalent hematologic disorder, with its incidence steadily increasing. Zebrafish, as an established model organism in biomedical research, has been extensively utilized for investigating various diseases. This review specifically focuses on the research of blood diseases in zebrafish in recent years, the study of MDS in mice, rats and zebrafish and the application of animal models, showing the important role played by zebrafish models among them.
【关键词】 骨髓增生异常综合征;
斑马鱼;
动物模型;
血液肿瘤疾病;
药物筛选;
【Key words】 Myelodysplastic syndrome; Zebrafish; Animal model; Hematologic oncologic disease; Drug screening;
【Key words】 Myelodysplastic syndrome; Zebrafish; Animal model; Hematologic oncologic disease; Drug screening;
【基金】 国家自然科学基金(81770102);华中科技大学重点研发项目(2018YFA0801000)
- 【文献出处】 发育医学电子杂志 ,Journal of Developmental Medicine(Electronic Version) , 编辑部邮箱 ,2024年01期
- 【分类号】R551.3;R-332
- 【下载频次】28