【摘要】 目的 建立了同时检测自来水中34种新污染物（Emerging Contaminants,ECs）的液相色谱-三重四极杆串联质谱（HPLC-MS/MS）方法，并对43个自来水样品进行检测，根据检测结果进行人体健康风险评估。方法样品经固相萃取富集提取后，40℃氮吹至近干，用甲醇-水溶液（95∶5,V/V）复溶至0.5 mL后测定；质谱采用AJS ESI电离源，MRM采集模式。使用标准品建立了34种ECs的母离子、子离子及保留时间的信息库。结果34种ECs在线性范围内平均线性相关系数（r）为0.995 9。检出限为0.01～0.60 ng/L，回收率为60.7%～119.8%，批内精密度为0.05%～9.89%，日间精密度为0.20%～14.40%。应用该方法在43个自来水样品中共检出15种物质，其中咖啡因检出率最高（84%），浓度范围为ND～74.42 ng/L；检出浓度最高的ECs是1,2,3-苯并三唑，浓度范围为ND～361.15 ng/L，检出率为44%。人类通过饮用自来水可能存在暴露风险。对其中检出的12种ECs进行了人体健康风险评估，发现统计的ECs风险熵值均<0.01。结论 该方法操作简单、灵敏度高、选择性强，能满足自来水中痕量ECs的检测需求，且利用该方法对43个自来水样品进行分析，检出的ECs对人体健康均不存在风险。更多还原

【Abstract】 Objective To establish a simultaneous detection approach for 34 emerging contaminants(ECs) in tap water by liquid chromatography-tandem mass spectrometry(HPLC-MS/MS). Human health risk assessment was performed according to the detection results from 43 tap water samples. Methods Tap water samples were concentrated and extracted by solid phase extraction, and then blown to near dry by nitrogen at 40℃. The sample extracts were dissolved in methanol-water solution(95:5, V/V) to 0.5 mL for analyzing. Agilent Jet Stream Electrospray Ionization(AJS ESI) and the multiple reaction monitoring(MRM) mode were performed for MS to acquire the data of 34 ECs. A database including precursor ion, product ion and retention times was established accordingly. Results The average linear correlation coefficients(r) of 34 kinds of ECs was 0.995 9. The limits of detection were 0.01 ～ 0.60 ng/L and the recoveries were between 60.7 % and 119.8 %. The intra-group precisions were between 0.05 % ～ 9.89 % and the intra-day precisions were between 0.20 % ～ 14.40 % for the spiked samples. The method was applied to analyze 43 tap water samples and a total of 15 ECs were detected. According to the results, the detection rate of caffeine was the highest(84 %), and the concentration range was ND ～ 74.42 ng/L. Among all the ECs detected, 1,2,3-benzotriazole had the highest concentration(ND ～ 361.15 ng/L), where detection rate was 44 %. Humans may be exposed to these ECs by drinking the tap water. The human health risk assessments of 12 kinds of ECs were carried out, however, the estimated risk was negligible(risk quotient < 0.01). Conclusion The method is simple, highly sensitive and selective, and could meet the detection needs of ECs at trace level in tap water. There was no human health risk posed for ECs identified in 43 tap water samples analyzed by this method.更多还原