【摘要】 目的 构建成人肿瘤患者化疗致周围神经病变症状管理循证实践方案。方法 以症状管理理论为框架，根据PIPOST循证问题进行结构化的文献检索，检索时间为建库至2022年1月31日。并对文献做质量评价，归纳综合最终纳入文献的相关证据，形成最佳实践推荐总结，制定符合现实情况且可行的具体实施策略，通过专家焦点小组访谈评价方案并修改，构建最终“成人肿瘤患者化疗致周围神经病变症状管理循证实践方案”。结果 共纳入1篇临床决策，2篇临床指南，2篇专家共识，1篇证据总结，1篇实践推荐，1篇系统评价的再评价和15篇系统评价/meta分析。形成最佳实践证据推荐包括38条证据，构建的方案包含6个维度及1份健康教育手册。方案总体设计专家评价得分为97.33%,各维度专家评价得分别为98.67%、98.10%、99.78%、99.26%、100%和99.56%,健康教育手册得分为99.89%。结论 成人患者化疗致周围神经病变症状管理循证方案遵循症状管理理论，在评估证据的可行性、适宜性、临床意义及有效性的前提下，充分引入证据，以达到证据在临床的转化，今后应进一步评价方案的临床可行性。更多还原

【Abstract】 Objective To constructan evidence-based protocol for symptom management of chemotherapy-induced peripheral neuropathy in adult patients. Methods With the theory of symptom management as the framework, a structured literature retrieval was conducted according to the PIPOST evidence-based question, the search time is from database establishment to January 31, 2022.and the quality of the literature was evaluated, and the relevant evidence eventually included in the literature were summarized and synthesized, and a summary of best practice recommendations was formed, practical and feasible specific implementation strategies was developed, and the evaluation protocol through expert focus group interviews was modified, and "Evidence-Based Practice Plan for Symptom Management of Chemotherapy-Induced Peripheral Neuropathy in Adult Cancer Patients" was finally constructed. Results A total of 1 clinical decision, 2 clinical guidelines, 2 expert consensus, 1 evidence summary, 1 practical recommendation, 1 re-evaluation of systematic evaluation, and 15 systematic evaluation/meta analysis were included. The best practice evidence recommendation included 38 pieces of evidence, and the constructed program included 6 dimensions and 1 health education manual.The expert evaluation score of the overall design of the protocol was 97.33%, the expert evaluation score of each dimension was 98.67%, 98.10%, 99.78%, 99.26%, 100%, and 99.56%,respectively, and the health education manual was 99.89%. Conclusion Evidence-based protocol for symptom management of chemotherapy-induced peripheral neuropathy in adult patients follows the theory of symptom management. Evidence is fully introduced to enable evidence transformation in clinical practice under the premise of assessing the feasibility, appropriateness, and clinical significance and effectiveness of evidence. In the future, the clinical feasibility of the proposed protocol should be further evaluated.更多还原