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衣原体对宿主细胞代谢与死亡的影响研究概况

Advance in Regulation of Host Cell Metabolism and Death by Chlamydia

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【作者】 梁兴露贾天军

【Author】 LIANG Xing-lu;JIA Tian-jun;Key Laboratory of Clinical Laboratory Diagnostics,Institute of Pathogenic Biology and Immunology,Hebei North University;

【通讯作者】 贾天军;

【机构】 河北北方学院临床检验诊断学重点实验室,病原生物学与免疫研究所

【摘要】 衣原体(Chlamydia)是专性寄生于胞内的病原体,感染宿主细胞后形成包涵体并分泌大量效应分子,为逃避宿主内吞插入并修饰包涵体膜的蛋白称为包涵体膜蛋白。衣原体凭借包涵体膜蛋白从宿主细胞摄取能量或代谢物以完成自身生长发育,也可凭借包涵体膜蛋白(inclusion membrane proteins, Incs)调控宿主细胞的死亡。论文从衣原体感染宿主细胞后对宿主细胞代谢与死亡的调节作用进行综述,以期为预防和治疗衣原体感染提供参考。

【Abstract】 Chlamydia is an obligatory intracellular pathogen.After infecting host cells, it forms inclusion bodies and secretes a large number of effector molecules.The proteins that insert and modify the membrane of inclusion bodies in order to escape host endocytosis are called inclusion membrane proteins(Incs).Chlamydia relies on Incs to absorb energy or metabolites from host cells to complete its own growth and development, and can also rely on Incs to regulate the death of host cells.This article reviews the regulation of host cell metabolism and death after Chlamydia infection in order to provide reference for prevention and treatment of Chlamydia infection.

【基金】 河北省自然科学基金项目(C2020405014)
  • 【文献出处】 动物医学进展 ,Progress in Veterinary Medicine , 编辑部邮箱 ,2024年09期
  • 【分类号】S852.67
  • 【下载频次】8
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