【摘要】 婴儿癫痫性痉挛综合征（Infantile epileptic spasm syndrome,IESS）是一种年龄依赖性癫痫性脑病，多于3～12个月内起病，常用抗癫痫发作药物（Anti-seizure medications,ASMs）疗效不佳，远期控制率低，复发率高，常遗留有发育落后/智力障碍、孤独症谱系障碍等后遗症。目前IESS的一线推荐治疗为促肾上腺皮质激素（Adrenocorticotropic hormone,ACTH）、肾上腺皮质激素和氨己烯酸，无效者可试用其他ASMs、生酮饮食和手术治疗等。本文将对IESS治疗现状及相关临床应用综述如下。更多还原

【Abstract】 Infantile epileptic spasm syndrome(IESS) is an age-dependent epileptic encephalopathy that onset within 3 ～ 12 months. Commonly used Anti-seizure medications(ASMs) have poor efficacy, low long-term control rate and high recurrence rate, and often leave behind sequelae such as developmental delay/intellectual disability, and autism spectrum disorders. At present, the first-line recommended treatments for IESS are Adrenocorticotropic hormone(ACTH), adrenocortical hormone and vigabatrin. If ineffective, other ASMs, ketogenic diets, and surgical treatments can be tried. This article will provide a review of the current status and related clinical applications of IESS treatment.更多还原