【摘要】 目的 研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis, PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae, SP)的药物敏感性。方法 回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果 160例PM患儿中，男103例，女57例；年龄15 d至15岁，其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%)，血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素；113例(70.6%)患儿有1个或多个颅外感染病灶；18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例，91.9%)，其次是精神萎靡(98例，61.3%)、呕吐(61例，38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症，常见并发症为硬膜下积液和/或积脓(43例，26.9%)、脑积水(24例，15.0%)、脑脓肿(23例，14.4%)、脑出血(8例，5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿，分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感；对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高；对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低；对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论 儿童PM多见于3月龄至<3岁婴幼儿，颅内并发症多发生在<1岁患儿，发热是PM患儿最常见的临床表现，硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。[中国当代儿科杂志，2024,26 (2):131-138]更多还原

【Abstract】 Objective To investigate the clinical characteristics and prognosis of pneumococcal meningitis(PM),and drug sensitivity of Streptococcus pneumoniae(SP) isolates in Chinese children.Methods A retrospective analysis was conducted on clinical information,laboratory data,and microbiological data of 160 hospitalized children under 15years old with PM from January 2019 to December 2020 in 33 tertiary hospitals across the country.Results Among the 160 children with PM,there were 103 males and 57 females.The age ranged from 15 days to 15 years,with 109 cases(68.1%) aged 3 months to under 3 years.SP strains were isolated from 95 cases(59.4%) in cerebrospinal fluid cultures and from 57 cases(35.6%) in blood cultures.The positive rates of SP detection by cerebrospinal fluid metagenomic nextgeneration sequencing and cerebrospinal fluid SP antigen testing were 40%(35/87) and 27%(21/78),respectively.Fiftyfive cases(34.4%) had one or more risk factors for purulent meningitis,113 cases(70.6%) had one or more extra-cranial infectious foci,and 18 cases(11.3%) had underlying diseases.The most common clinical symptoms were fever(147cases,91.9%),followed by lethargy(98 cases,61.3%) and vomiting(61 cases,38.1%).Sixty-nine cases(43.1%)experienced intracranial complications during hospitalization,with subdural effusion and/or empyema being the most common complication [43 cases(26.9%)],followed by hydrocephalus in 24 cases(15.0%),brain abscess in 23 cases(14.4%),and cerebral hemorrhage in 8 cases(5.0%).Subdural effusion and/or empyema and hydrocephalus mainly occurred in children under 1 year old,with rates of 91%(39/43) and 83%(20/24),respectively.SP strains exhibited complete sensitivity to vancomycin(100%,75/75),linezolid(100%,56/56),and meropenem(100%,6/6).High sensitivity rates were also observed for levofloxacin(81%,22/27),moxifloxacin(82%,14/17),rifampicin(96%,25/26),and chloramphenicol(91%,21/23).However,low sensitivity rates were found for penicillin(16%,11/68) and clindamycin(6%,1/17),and SP strains were completely resistant to erythromycin(100%,31/31).The rates of discharge with cure and improvement were 22.5%(36/160) and 66.2%(106/160),respectively,while 18 cases(11.3%) had adverse outcomes.Conclusions Pediatric PM is more common in children aged 3 months to under 3 years.Intracranial complications are more frequently observed in children under 1 year old.Fever is the most common clinical manifestation of PM,and subdural effusion/emphysema and hydrocephalus are the most frequent complications.Nonculture detection methods for cerebrospinal fluid can improve pathogen detection rates.Adverse outcomes can be noted in more than 10% of PM cases.SP strains are high sensitivity to vancomycin,linezolid,meropenem,levofloxacin,moxifloxacin,rifampicin,and chloramphenicol.[Chinese Journal of Contemporary Pediatrics,2024,26(2):131-138]更多还原