【摘要】 目的 系统评价眼底相干光层析血管成像术(OCTA)检测开角型青光眼(OAG)术后血管密度(VD)改变情况。方法 计算机检索中国知网、万方、维普、中国生物医学文献服务系统(SinoMed)、PubMed、Embase和Web of Science数据库，搜集OCTA检测OAG术后VD改变的研究，检索时限均为建库至2024年5月。由两名评价员独立进行文献筛选、提取资料并评价纳入研究的偏倚风险；定性系统评价采用描述性分析，采用R软件进行meta分析并计算均数差(MD)及其95%CI。结果 共纳入13项研究，包括OAG患者472例，涉及被检测眼睛500只。meta分析结果显示，与术前比较，术后6个月视神经乳头(ONH)周围、鼻上区、颞下区、颞上区、上颞区和上鼻区的VD明显降低(P<0.05);术后6个月黄斑旁、黄斑旁上半区、黄斑周围上半区、黄斑旁上方和黄斑周围上方的VD明显升高(P<0.05)。结论 OCTA能够有效检测OAG患者术后VD变化情况，预测青光眼术后视功能变化，可作为评估OAG患者临床治疗效果的有效检测手段。更多还原

【Abstract】 Objective To systematically evaluate the value of optical coherence tomography angiography(OCTA) for detecting the vessel density(VD) changes after open-angle glaucoma(OAG) surgery.Methods The studies on OCTA for detecting the VD changes after OAG surgery were searched in the CNKI,WanFang, VIP,SinoMed, PubMed, Embase and Web of Science databases from the database establishment to May 2024.Literature screening, data extraction and risk of bias assessment of included studies were conducted independently by two reviewers.Descriptive analysis was adopoted for the systematic evaluation, the meta analysis was conducted by using the R software and mean difference(MD) and its 95%CI were calculated.Results A total of 13 studies were included, involving 472 patients with 500 tested eyes.The results of meta-analysis showed that compared with pre-surgery, VD around the optic nerve head(ONH) and in nasal superior, temporal inferior, temporal superior, superior temporal and superior nasal regions at postoperative 6 months were significantly decreased.VD in the perimacular, perimacular superior hemisphere, permacular superior hemisphere, perimacular superior and permacular superior regions at postoperative 6 months were significantly increased.Conclusion OCTA could effectively detect the postoperative VD changes in the patients with OAG and predict postoperative visual function changes in glaucoma, and could serve as an effective test means for assessing the clinical treatment effect of the patients with OAG.更多还原