【摘要】 目的：分析职业酸雾暴露与作业工人生物衰老加速的关联性，并阐明其相关危险因素。方法：选取341名男性职业酸雾接触工人和201名男性无职业接触的工人作为研究对象，分别为暴露组和对照组。通过问卷调查和体格检查收集2组研究对象一般资料，检测2组研究对象血清中红细胞计数（RBC）、血小板数（PLT）和白蛋白（ALB）、尿素（Urea）、肌酐（CR）、甘油三酯（TG）、总胆固醇（TC）、糖化血红蛋白（HBA1c）及超敏C反应蛋白（Hs-CRP）水平。采用KlemeraDoubal法（KDM）构建复合衰老指标KDM-生物年龄（BA）(KDM-BA)，选择2009年中国健康与营养调查（CHNS）数据库样本训练模型参数，计算BA加速。基于人群特征进行分层，分析不同人群特征2组研究对象的BA加速，采用广义线性模型分析酸雾暴露对BA加速的影响因素。结果：选择2009年CHNS数据库中20～79岁的样本训练模型参数，共纳入8 133例样本，其中男性人群样本3 788例。2组研究对象血清中Urea、CR、HBA1c、ALB和TC水平及收缩压（SBP）、总工龄、睡眠时长和体质量指数（BMI）比较差异均有统计学意义（P<0.05）；与对照组比较，暴露组研究对象BA加速明显升高（P<0.05）。在全人群和暴露组中，与不吸烟组比较，吸烟组研究对象BA加速明显升高（P<0.05）；在全人群、对照组和暴露组中，随着BMI升高，不同BMI组研究对象BA加速明显降低（P<0.05）。与对照组比较，暴露组研究对象<40岁、总工龄4～7年、汉族、未婚、吸烟和睡眠时长6～7 h及超体质量人群中BA加速明显升高（P<0.05）。酸雾暴露、吸烟和BMI与BA加速有关联（β=0.72, 95%CI:0.24—1.21; β=0.59, 95%CI:0.11—1.06; β=-0.29, 95%CI:-0.35—-0.22）。结论：职业酸雾暴露可能加速作业工人生物衰老，酸雾是加速机体生物衰老的危险因素。更多还原

【Abstract】 Objective:To discuss the association between occupational acid fog exposure and accelerated biological aging of the workers, and to clarify its related risk factors. Methods:A total of 341 male workers exposed to occupational acid fog and 201 male workers without occupational exposure were selected as the study subjects, and they were divided into exposure group and control group, respectively. The general informations of the subjects in two groups were collected through questionnaires and physical examinations. The levels of red blood cell count(RBC), platelet count(PLT), albumin(ALB), urea(Urea), creatinine(CR), triglycerides(TG), total cholesterol(TC),glycated hemoglobin(HBA1c), and high-sensitivity C-reactive protein(Hs-CRP) in serum of the subjects in two groups were detected. The Klemera-Doubal method(KDM) was used to construct the composite aging measure, KDM-biological age(BA)(KDM-BA). The model parameters were trained using samples from the 2009 China Health and Nutrition Survey(CHNS) Database to calculate the BA acceleration of the subjects in two groups; stratified analysis based on the population characteristics was conducted to analyze the BA of the subjects in two groups with different population characteristics; generalized linear model was used to analyze the factors influencing BA acceleration due to acid fog exposure. Results:The model parameters were trained using samples from the 2009 CHNS Database,including 8 133 cases aged 20-79 years, of which 3 788 were male. The levels of Urea, CR, HBA1c,ALB, and TC, as well as systolic blood pressure(SBP), total working years, sleep duration, and body mass index(BMI) of the subjects between two groups had significant differences(P<0.05). Compared with control group, the BA acceleration of the subjects in exposure group was significantly increased(P<0.05). In entire population and exposure group, the BA acceleration in the smokers was significantly higher than that in the non-smokers(P<0.05). In entire population, control group, and exposure group, the BA accelerations of the subjects in different BMI groups were significantly decreased with the increase of BMI(P<0.05). Compared with control group, the BA acceleration of the subjects in exposure group was significantly increased(P<0.05), including those under 40 years old, with total working years of 4-7 years, Han nationality, unmarried, smokers, and sleep duration 6-7 h, and with overweight. Acid fog exposure, smoking, and BMI were associated with the BA acceleration(β =0.72, 95% CI: 0.24—1.21; β =0.59, 95% CI: 0.11—1.06; β =-0.29, 95% CI:-0.35—-0.22). Conclusion:Occupational acid fog exposure may accelerate the biological aging in the workers, and acid fog is a risk factor to accelerate the biological aging of the body.更多还原