【摘要】 目的 了解甘肃省东乡族人群Duffy、Kidd、Diego血型系统等位基因频率多态性分布。方法 2017年1—12月随机抽取甘肃省东乡族无血缘关系献血者100名，采用荧光PCR法检测献血者红细胞Duffy、Kidd、Diego血型系统等位基因。结果 东乡族人群Duffy、Kidd、Diego血型系统等位基因频率为：Fy~*01为0.835、Fy~*02为0.165;Jk~*01为0.570、Jk~*02为0.430;DI~*01为0.020、DI~*02为0.980。未发现Fy(a-b-)、Jk(a-b-)、Di(a+b-)稀有表型。Duffy、Kidd、Diego血型系统等位基因对偶抗原Fya/Fyb、Jka/Jkb、Dia/Dib的不配合率分别为：23.76%、37.01%、3.84%。结论 甘肃省东乡族人群Duffy、Kidd、Diego血型系统等位基因呈多态性分布，具有独特的民族分布特征。更多还原

【Abstract】 Objective To investigate the allele frequencies polymorphic distribution of Duffy, Kidd and Diego blood group systems in Dongxiang ethnic group in Gansu Province. Methods Blood samples of 100 unrelated blood donors were randomly selected from Dongxiang ethnic group in Gansu from January to December 2017. Allelic typing of Duffy,Kidd and Diego blood groups was performed by fluorescence PCR. Results The allele frequencies of Duffy, Kidd, and Diego blood group systems of Dongxiang ethnic group were 0.835 for Fy~*01, 0.165 for Fy~*02, 0.570 for Jk~*01, 0.430 for Jk~*02, 0.020 for DI~*01, 0.980 for DI~*02, respectively. No Fy(a-b-), Jk(a-b-), Di(a+b-) rare phenotypes were found. The antigen incompatibility rates of Fya/Fyb, Jka/Jkb, Dia/Dibof Duffy, Kidd, and Diego blood group systems were 23.76%,37.01% and 3.84%, respectively. Conclusion The allele frequencies distribution of Duffy, Kidd and Diego blood group systems in Dongxiang ethnic group in Gansu were polymorphic and has unique ethnic distribution characteristics.更多还原