【摘要】 为探究铁皮石斛醇提物对抗生素致肠道菌群失调小鼠肠道菌群的影响，本试验分别设置空白组和肠道菌群失调模型组（灌胃盐酸林可霉素120 mg/kg），分别给予模型组常温水、铁皮石斛醇高剂量（6 g/kg）、低剂量（1.5 g/kg）处理，观察各处理小鼠一般情况、TNF-α、IL-1水平、短链脂肪酸水平、肠道菌群组成及丰度和多样性。结果表明，铁皮石斛高、低剂量组小鼠精神一般情况好转，血清TNF-α、IL-1水平与模型组相比明显降低，短链脂肪酸水平明显提高；肠道菌群物种组成与模型组存在差异，但其丰度及多样性差异不明显。铁皮石斛醇提物对抗生素致肠道菌群失调小鼠的肠道菌群具有一定的改善作用。更多还原

【Abstract】 To explore the effects of ethanol extract from Dendrobium officinale on the gut microbiota of antibiotic induced dysbiosis mice, a blank group and a gut microbiota dysbiosis model group(gavage of lincomycin hydrochloride 120 mg/kg)were set up, respectively. The model group was treated with normal water, high(6 g/kg)and low dose(1.5 g/kg)of ethanol extract from Dendrobium officinale, and the effects of each treatment on the general condition, TNF-α,IL-1 levels, short chain fatty acid levels, gut microbiota composition, richness, and diversity of mice were observed.The results showed that the general mental condition of mice in the high-dose and low-dose groups of Dendrobium officinale improved, and the levels of serum TNF-α and IL-1 were significantly reduced compared to the model group,while the levels of short chain fatty acids were significantly increased. There were differences in the species composition of gut microbiota compared to the model group, but no significant differences in richness and diversity. The ethanol extract of Dendrobium officinale had a certain improvement effects on the gut microbiota of antibiotic induced intestinal dysbiosis mice.更多还原