【摘要】 目的：使用中医传承辅助平台软件统计分析中医药治疗梅核气的组方配伍规律，为临床组方用药提供理论指导。方法：通过收集并筛选中国期刊全文数据库中运用中医药方剂治疗梅核气的文献，借助中医传承辅助平台软件V2.5建立方剂数据库以分析其性味归经、用药频数、关联度、关联规则，并基于复杂系统熵聚类方法演化核心组方和新方。结果：筛选出治疗梅核气方剂271首，涉及中药214种，四气五味与归经分析显示，治疗梅核气的药物药性以温、寒、平为主，药味以辛、苦、甘多见，脏腑归经多归脾经、肺经、胃经、肝经。统计分析得出高频用药46味，前15味依次是半夏、茯苓、厚朴、甘草、柴胡、陈皮、生姜、桔梗、香附、枳壳、紫苏、白芍、郁金、紫苏梗、白术，这些药物多有燥湿化痰、理气宽中、疏肝解郁、补脾益气、消痞散结等功效；高频药物组合36组，前10组为半夏-茯苓、半夏-厚朴、厚朴-茯苓、半夏-厚朴-茯苓、半夏-柴胡、半夏-甘草、柴胡-茯苓、甘草-茯苓、生姜-半夏、半夏-紫苏。进一步聚类分析后，得到18条核心药物、9首新方。结论：梅核气的中医辨证思路以痰气互结、升降失调、宣肃失常为出发点，治疗思路以疏肝健脾、化痰理气为主，同时也注重和胃、固肾、宣肺等方法的运用。更多还原

【Abstract】 Objective: The purpose of this study was to analyze and summarize TCM medication rules on globus hystericus based on TCM inheritance support system platform, so as to provide theoretical guidance for clinical prescription medication. Methods:The literature on treating globus hystericus with TCM prescriptions in CNKI database was collected and selected according to screening criteria. The database was established by the TCM inheritance support system platform V2.5 to analyze the properties,flavors and meridian-tropism, used frequency, association degree, and the association rules. The core combination and new prescriptions were evolved by the complex system entropy clustering method. Results: A total of 271 prescriptions for treating globus hystericus were retrieved, involving 214 kinds of TCM medicinal material. The results of data analysis showed that the properties of the medicines in the prescriptions were mainly warm, cold and moderate, that the main flavors were pungent, bitter and sweet, and the meridian-tropism of viscera was mainly spleen meridian, lung meridian, stomach meridian and liver meridian. The statistical analysis showed that there were 46kinds of Chinese medicinal material with high frequency. The first 15 kinds were Banxie(Rhizoma Pinelliae), Fuling(Poria), Houpo(Cortex Magnoliae Officinalis), Gancao(Radix Glycyrrhizae), Chaihu(Radix Bupleuri), Chenpi(Pericarpium Citri Reticulatae), Shengjiang(Rhizoma Zingiberis Recens), Jiegeng(Radix Platycodonis), Xiangfu(Rhizoma Cyperi), Zhiqiao(Fructus Aurantii), Zisu(Perilla),Baishao(Radix Paeoniae Alba), Yujin(Radix Curcumae), Zisugeng(Caulis Perillae), Baizhu(Rhizoma Atractylodis Macrocephalae).These 15 medicines mostly had the effects of drying dampness and resolving phlegm, regulating Qi( 气), soothing liver and resolving depression, tonifying spleen and Qi, eliminating swelling and dispersing knot, etc.. There were 36 high-frequency medicine combinations,and the first 10 combinations were Banxia-Fuling, Banxia-Houpo, Houpo-Fuling, Banxia-Houpo-Fuling, Banxia-Chaihu, Banxia-Gancao,Chaihu-Fuling, Gancao-Fuling, Shengjiang-Banxia, Banxia-Zisu. After further clustering analysis, 18 potential core medicines and 9 new prescriptions were obtained. Conclusion: The TCM syndrome differentiation and treatment thought of globus hystericus is mainly based on the combination of phlegm and Qi, the disorder of rising and falling, and pulmonary dysfunction. The treatment methods are mainly soothing liver and strengthening spleen, resolving phlegm and regulating Qi. At the same time, it also pays attention to the application of the methods such as harmonizing stomach, strengthening kidney, and ventilating lung.更多还原