【摘要】 目的：观察双嘧达莫联合特布他林治疗小儿毛细支气管炎（BC）的疗效。方法：选择本院2018年6月—2021年6月收治的BC患儿82例，以随机数字表法分为观察组（42例）与对照组（40例），对照组在常规治疗基础上给予特布他林治疗，观察组在对照组基础上联用双嘧达莫治疗，比较两组临床疗效、临床症状体征消失时间、血清炎性介质及不良反应。结果：观察组治疗总有效率为97.62%，高于对照组的82.50%(P<0.05)；观察组治疗后咳嗽、发热、喘憋、肺部啰音消失时间早于对照组（P<0.05）；观察组血清IL-6、TNF-α水平低于对照组（P<0.05）；观察组与对照组不良反应发生率比较，差异无统计学意义（P>0.05）。结论：双嘧达莫联合特布他林治疗小儿BC疗效确切，有利于促进患儿症状体征改善，减轻机体炎症反应，安全性高。更多还原

【Abstract】 Objective: To observe the efficacy of dipyridamole combined with terbutaline in the treatment of children with bronchiolitis. Methods: A total of 82 children with BC admitted to our hospital from June 2018 to June 2021 were selected.The random number table method was used as the observation group( 42 cases) and the control group( 40 cases). Both groups were given routine symptomatic treatment. On this basis, the control group was treated with terbutaline, and the observation group was treated with dipyridamole combined with terbutaline. The clinical efficacy, disappearance time of clinical symptoms and signs, serum inflammatory mediators and adverse reactions were compared between the two groups.Results: The total effective rate of treatment in the observation group was 97.62%, which was higher than 82.50% in the control group(P<0.05). The disappearance time of cough, fever, wheezing and pulmonary rales in the observation group after treatment was earlier than that in the control group(P<0.05). The serum levels of IL-6 and TNF-α in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05). Conclusion: Dipyridamole combined with terbutaline is effective in the treatment of children with BC, which is beneficial to improve the symptoms and signs of children, reduce the body’s inflammatory response, and has few adverse drug reactions and high safety.更多还原