【摘要】 目的 探讨苏黄止咳胶囊联合肺康复辅助治疗慢性阻塞性肺疾病急性加重期（Acute exacerbation of chronic obstructive pulmonary disease, AECOPD）痰热阻肺型患者疗效及对心肺功能、炎症状态的影响。方法 选择医院2021年1月—2022年1月收治的100例AECOPD患者作为研究对象，使用随机数字表通过简单随机的方法将入组患者分为研究组与对照组每组50例。所有患者在接受西医常规治疗的基础上，给予对照组肺康复辅助治疗，给予研究组苏黄止咳胶囊联合肺康复辅助治疗，两组治疗时间均为1周，比较两组临床疗效、治疗前后中医证候积分、肺功能指标[第1秒用力呼气容积（Forced expiratory volume in 1 second, FEV₁）、用力肺活量（Forced vital capacity, FVC）及FEV₁占FVC预计值百分比（FEV₁/FVC）]、炎症指标[C反应蛋白（C reactive protein, CRP）、降钙素原（Procalcitonin, PCT）]以及不良反应发生情况。结果 研究组与对照组总有效率分别为96.00%和80.00%,差异具有统计学意义（P<0.05）,研究组治疗后咳嗽、喘息、咳痰、胸部胀满、发热、口渴、大便干积分以及CRP、PCT水平均明显低于对照组（P<0.05）,研究组治疗后FEV₁、FVC及FEV₁/FVC均明显高于对照组（P<0.05）,两组治疗期间不良反应发生率差异无统计学意义（P>0.05）。结论 苏黄止咳胶囊联合肺康复辅助治疗慢性阻塞性肺疾病急性加重期具有较好的疗效，对于改善患者肺功能、减轻炎症反应具有明显效果，且具有较高的安全性，无心、肝、肾脏器方面的不良反应发生，适合推广应用。更多还原

【Abstract】 Objective To investigate the effect of Suhuang Zhike Capsule（苏黄止咳胶囊） combined with pulmonary rehabilitation in adjuvant treatment of patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with phlegm-heat obstructing lung type and the effect of cardiopulmonary function and inflammatory state. Methods A total of 100 AECOPD patients admitted to the hospital from January 2021 to January 2022 were selected as the research subjects, and the enrolled patients were divided into the study group and the control group with 50 cases in each group by a simple random method using a random number table. On the basis of conventional western medicine treatment, the patients were given pulmonary rehabilitation adjuvant therapy in the control group, and Suhuang Zhike Capsule combined with pulmonary rehabilitation adjuvant therapy in the study group. The treatment time of both groups was 1 week. Syndrome score, pulmonary function index[forced expiratory volume in 1 second（FEV₁）,forced vital capacity（FVC） and percentage of FEV₁ to predicted FVC value（FEV₁/FVC）],inflammatory index[C-reactive protein（CRP）,calcitonin Progenitor（PCT）] and the occurrence of adverse reactions of two groups were compared. Results The total effective rates of the study group and the control group were 96.00% and 80.00%,respectively, and the difference was statistically significant（P<0.05）. After treatment, the study group had cough, wheezing, expectoration, fullness of the chest, fever, thirst, and dry stool. The scores, and the levels of CRP and PCTwere significantly lower than those in the control group（P<0.05）. After treatment, the values of FEV₁,FVC and FEV₁/FVC in the study group were significantly higher than those in the control group（P<0.05）. Adverse reactions rates in the two groups during treatment had no significant difference（P>0.05）. Conclusion Suhuang Zhike Capsule combined with pulmonary rehabilitation has good curative effect in the treatment of AECOPD. It is suitable for popularization and application.更多还原