【摘要】 肾病综合征是一类好发于儿童期间的肾脏疾病，患儿在发病和激素治疗过程中均容易发生血清维生素D水平下降，而引发一系列病理生理改变。目前认为，应用维生素D防治肾病综合征能够改善患儿免疫水平、足细胞功能、骨代谢和蛋白尿等，不仅有利于恢复肾脏功能，也对疾病带来的其他系统损害起到一定防治作用。因此，本文就肾病综合征患儿血清维生素D水平下降机制，以及予患儿补充外源性维生素D的作用机制进行综述，期望能够服务于临床。更多还原

【Abstract】 Nephrotic syndrome is a kind of kidney disease that occurs in children. In the course of disease and hormone therapy, the serum vitamin D level of children is prone to decrease, which leads to a series of pathophysiological changes. At present, it is believed that the application of vitamin D to prevent and treat nephrotic syndrome can improve the immune level, podocyte function, bone metabolism and proteinuria in children, which is not only conducive to restoring kidney function, but also play a certain role in the prevention and treatment of other system damage caused by the disease. Therefore, the present review of the mechanism of decreased serum vitamin D levels in children with nephrotic syndrome, and the mechanism of action of exogenous vitamin D supplementation in children, is expected to serve the clinical practice.更多还原