【摘要】 目的 检测妊娠期梅毒患者血清白细胞介素-17(IL-17)、白细胞介素-21(IL-21)的表达情况，并探讨二者与患者妊娠结局的关系。方法 选择2019年1月—2021年6月杭州市萧山区第一人民医院收治的51例妊娠期梅毒患者作为研究对象，根据不良妊娠结局发生情况分为发生组与未发生组，统计并比较不同预后的妊娠期梅毒患者各项资料及血清IL-17、IL-21水平，采用点二列相关性分析妊娠期梅毒患者血清IL-17、IL-21水平与妊娠结局的关系。结果 51例患者中20例出现不良妊娠结局，占39.22%,其中自然流产3例(5.88%),早产8例(15.69%),死胎3例(5.88%),新生儿窒息6例(11.76%);发生组与未发生组基线资料比较，差异无统计学意义(P>0.05);发生组梅毒抗体滴度>1:8占比较未发生组高，血清IL-17、IL-21水平较未发生组高，差异有统计学意义(P<0.05);点二列相关性分析结果显示，血清IL-17、IL-21水平与不良妊娠结局的发生风险成正相关(r>0,P<0.05)。结论 妊娠期梅毒患者血清IL-17、IL-21水平与不良妊娠结局有关，血清IL-17、IL-21水平异常升高可增加患者不良妊娠结局发生风险。更多还原

【Abstract】 Objective This paper aims to detect the serum levels of interleukin-17(IL-17) and interleukin-21(IL-21) in patients with syphilis and explore their relationship with pregnancy outcome. Methods Fifty one pregnant syphilis patients treated in Xiaoshan District First People’s Hospital from January 2019 to June 2021 were selected as the research subjects. According to the occurrence of adverse pregnancy outcomes, they were divided in to occurrence group and non-occurrence group. The data of pregnant syphilis patients with different prognosis and their serum levels of IL-17 and IL-21 were counted and compared. The relationship between serum IL-17, IL-21 levels and pregnancy outcomes in patients with syphilis during pregnancy was analyzed by point biserial correlation. Results Among the 51 patients, 20 had adverse pregnancy outcomes, accounting for 39.22%, of which there were 3 cases of spontaneous abortion(5.88%), 8 cases of premature birth(15.69%), 3 cases of stillbirth(5.88%), and 6 cases of neonatal asphyxia(11.76%); there was no statistical significance on the difference in baseline data between the occurrence group and the non-occurrence group(P>0.05). The proportion of syphilis antibody titer >1:8 in the occurrence group was higher than that in the non-occurrence group, and the serum levels of IL-17 and IL-21 were higher than those in the non-occurrence group, with the difference statistically significant(P<0.05); point biserial correlation analysis show that the serum levels of IL-17 and IL-21 were positively correlated with the risk of adverse pregnancy outcome(r>0, P<0.05). Conclusion The serum levels of IL-17 and IL-21 in patients with syphilis during pregnancy are related to adverse pregnancy outcomes. The abnormal increase of serum IL-17 and IL-21 levels can increase the risk of adverse pregnancy outcomes.更多还原