【摘要】 目的 探讨童年期创伤与抑郁症患者血浆脂联素水平的相关性。方法 纳入抑郁症患者121例，健康对照39名（对照组）。采用童年期创伤问卷（childhood trauma questionnaire,CTQ-SF）评估童年期虐待和忽视经历，根据CTQ-SF评分将抑郁症患者分为创伤组（n=53）和无创伤组（n=68）。采用17项汉密尔顿抑郁量表(Hamilton depression scale-17,HAMD₁₇)和汉密尔顿焦虑量表（Hamilton anxiety scale,HAMA）分别评定患者的抑郁、焦虑症状严重程度。采用酶联免疫吸附法测定受试者的血浆脂联素水平。结果 创伤组的血浆脂联素水平[3.82（2.44,4.92）μg/mL]低于无创伤组[4.64（2.98,6.43）μg/mL,P=0.01]和对照组[6.29（4.54,7.51）μg/mL,P<0.01]，无创伤组的血浆脂联素水平低于对照组（P<0.01）。相关分析显示抑郁症患者血浆脂联素水平与童年期创伤呈负相关（r=-0.34,P<0.01）。多因素线性回归分析表明，抑郁症患者的血浆脂联素水平与童年期创伤得分呈负关联（β=-0.05,P<0.01）。结论 经历过童年期创伤的抑郁症患者具有更低的血浆脂联素水平，抑郁症患者血浆脂联素水平下降可能与童年期创伤有关。更多还原

【Abstract】 Objective To explore the correlation between childhood trauma and plasma adiponectin levels in patients with depression.Methods A total of 121 patients with depression and 39 healthy controls （control group） were enrolled.Childhood trauma questionnaire （CTQ-SF） was used to assess the experience of childhood abuse and neglect,and the patients with depression were divided into trauma group （n=53） and non-trauma group （n=68） according to the CTQ-SF score.The 17-item Hamilton depression scale-17 (HAMD₁₇) and the Hamilton anxiety scale （HAMA） were used to evaluate the severity of depression and anxiety symptoms,respectively.Plasma adiponectin levels of subjects were measured by enzyme-linked immunosorbent assay.Results The plasma adiponectin level of trauma group[3.82 （2.44,4.92）μg/mL]was significantly lower than that of non-trauma group[4.64 （2.98,6.43）μg/mL,P=0.01]and the control group[6.29 （4.54,7.51）μg/mL,P<0.01].The plasma adiponectin level of non-trauma group was lower than that of the control group （P<0.01）.Correlation analysis showed that plasma adiponectin level in patients with depression was negatively correlated with childhood trauma （r=-0.34,P<0.01）.Multivariate linear regression analysis showed that plasma adiponectin level was negatively correlated with childhood trauma scores in patients with depression （β=-0.05,P<0.01）.Conclusions Patients with depression who have experienced childhood trauma have lower plasma levels of adiponectin,and childhood trauma may be associated with decreased plasma adiponectin levels in patients with depression.更多还原