【摘要】 单核苷酸多态性(single nucleotide polymorphism, SNP)作为第三代分子遗传标记，因其在遗传疾病、基因进化、适应和物种、医学等领域的研究重要性而受到广泛的关注。其特征是位点数量多、分布广泛、遗传稳定、通量高，适用于快速、规模化筛查，目前已广泛应用于多种细菌分子分型。本文就SNP技术的概况、与其他分型方法的比较及其在细菌分子分型中的应用进行综述。更多还原

【Abstract】 Single nucleotide polymorphisms(SNPs), third generation molecular genetic markers, have attracted extensive attention because of their importance in research on genetic diseases, gene evolution, adaptation, species, medicine and other fields. SNPs are found in large numbers, with a wide distribution, stable genetics and high throughput. Moreover, SNPs are suitable for rapid and large-scale screening. These genetic markers have been widely used in molecular typing for a variety of bacteria. Herein, the current status of SNP technology is discussed and compared with other typing methods, and its applications in bacterial molecular typing are reviewed.更多还原