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苦参汤联合氟康唑胶囊治疗真菌性阴道炎患者的效果
Effects of Kushen decoction combined with Fluconazole capsules in treatment of colpitis mycotica
【摘要】 目的:观察苦参汤联合氟康唑胶囊治疗真菌性阴道炎患者的效果。方法:选取2019年1—6月该院收治的103例患者进行前瞻性研究,按照随机数字表法分为对照组51例和研究组52例。对照组采用氟康唑胶囊治疗,研究组在对照组基础上联合苦参汤治疗,比较两组临床疗效,治疗前后中医证候积分、阴道分泌物炎性因子[白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF-α)]水平,不良反应发生率,以及治疗后6、12个月复发率。结果:治疗后,两组主症和次症中医证候积分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组治疗总有效率为94.23%,高于对照组的80.39%,差异有统计学意义(P<0.05);治疗后,两组阴道分泌物IL-6、IL-8、TNF-α水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);治疗后6、12个月,研究组复发率均低于对照组,差异有统计学意义(P<0.05)。结论:苦参汤联合氟康唑胶囊治疗真菌性阴道炎患者可提高治疗总有效率,降低中医证候积分、阴道分泌物炎性因子水平和复发率,优于单纯氟康唑胶囊治疗。
【Abstract】 Objective: To observe effects of Kushen decoction combined with Fluconazole capsules in treatment of colpitis mycotica.Methods: A prospective study was conducted on 103 patients admitted to the hospital from January to June 2019. They were divided into control group(51 cases) and study group(52 cases) according to the random number table method. The control group was treated with Fluconazole capsules,while the study group was treated with Kushen decoction on the basis of that of the control group. The clinical efficacy, the TCM syndrome scores before and after the treatment, the levels of inflammatory factors [interleukin(IL)-6, IL-8, tumor necrosis factor(TNF-α)] in vaginal secretions, the incidence of adverse reactions, and the recurrence rates 6 and 12 months after the treatment were compared between the two groups. Results: After the treatment, the TCM syndrome scores of main and secondary symptoms in the two groups were lower than those before the treatment, those in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). The total effective rate of the study group was 94.23%, which was higher than 80.39% of the control group, and the difference was statistically significant(P<0.05). After the treatment,the levels of IL-6, IL-8 and TNF-α in the vaginal secretions of the two groups were lower than those before the treatment, those in the study group were lower than those in the control group, and the differences were statistically significant(P<0.05). However, there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). 6 and 12 months after the treatment, the recurrence rates of the study group were lower than those of the control group, and the differences were statistically significant(P<0.05). Conclusions: Kushen decoction combined with Fluconazole capsule in the treatment of colpitis mycotica can improve the total effective rate of treatment and reduce the TCM syndrome score, the inflammatory factor levels in the vaginal secretion and the recurrence rate. Moreover, it is superior to single Fluconazole capsule treatment.
【Key words】 Kushen decoction; Fluconazole capsules; Vaginitis; TCM syndrome score; Inflammatory factor; Adverse reaction; Recurrence rate;
- 【文献出处】 中国民康医学 ,Medical Journal of Chinese People’s Health , 编辑部邮箱 ,2023年02期
- 【分类号】R711.31
- 【下载频次】25