【摘要】 胰腺癌仍然是最致命的恶性肿瘤之一，对传统疗法的抵抗使其生存率在过去几十年内几乎未有改善，而基于肿瘤免疫的胰腺癌治疗策略，如免疫检查点抑制剂、治疗性疫苗和联合免疫疗法正显示出新的治疗希望。尽管临床试验中探索的诸多免疫疗法尚未报道出显著的治疗效果，但毋庸置疑的是免疫治疗将是胰腺癌预后改善甚至治愈的重要希望。本文介绍了目前胰腺癌免疫疗法的相关进展及遇到的瓶颈，并提出了进一步的优化方向和解决方案，希望为胰腺癌免疫治疗发展提供参考。更多还原

【Abstract】 Pancreatic cancer remains as one of the most lethal malignancies. Resistance to conventional therapies has led to little improvement in the survival of pancreatic cancer patients over the past few decades.Immune-based treatment strategies for pancreatic cancer, such as immune-checkpoint inhibitors, therapeutic vaccines, and combination immunotherapies show promise. Many immunotherapies have been explored in clinical trials, but they have yet to show significant therapeutic effects. Nevertheless, immunotherapy is inevitably the future of pancreatic cancer cure. This article introduces the current research progress and bottlenecks of immunotherapy for pancreatic cancer and puts forward further optimization directions and solutions. We hope to provide a reference for the future use of immunotherapy for pancreatic cancer.更多还原