【摘要】 目的 收集全国真菌病监测网四川省中心真菌血流感染数据，整理分析病原菌分布特点及抗真菌药物敏感性情况，为四川省真菌血流感染提供流行病学数据。方法 研究28家医院2019年1月1日—2021年12月31日门急诊及住院患者真菌血流感染的数据，采用Whonet 5.6及Microsoft Excle数据透视表功能分析真菌血流感染的临床资料及实验室信息。结果 2019年1月1日—2021年12月31日28家医院上报数据中的1 220株真菌中，念珠菌属占88.8%(1 083/1 220),以白念珠菌为主，占35.3%(431/1 220);新生隐球菌位于总分离株数的第5位，占8.3%(101/1 220)。男性占比56.6%(690/1220),女性患者相比较少(43.4%,530/1 220);其中中老年患者(>46岁)79.8%,34.8%来自于重症监护室。白念珠菌对氟康唑的敏感性最高(85.7%);热带念珠菌对氟康唑和伏立康唑的耐药率分别为43.4%和43.3%,且逐年上升。分离的101株新生隐球菌对两性霉素B、氟胞嘧啶、氟康唑、伏立康唑和伊曲康唑均存在不同的非野生株，比例分别为5.0%、2.5%、11.8%、5.7%和8.5%;每家医院分离病原菌的数量排序存在一定差异，大多数医院以白念珠菌为主，但儿童专科性医院近平滑念珠菌分离数最多。结论 真菌血流感染病原菌及其抗真菌药物敏感性存在地域性特点，准确掌握所在地区病原菌流行病学资料可以为临床选择抗真菌药物提供依据。更多还原

【Abstract】 Objective To collect the fungal bloodstream infection data from the Sichuan Provincial Center of China Fungal Disease Surveillance System, to analyze the distribution characteristics and the susceptibility to antifungal drugs of pathogens, and to provide epidemiological data for fungal bloodstream infections in Sichuan Province. Methods The data of outpatient, emergency, and inpatient fungal bloodstream infections in 28 hospitals from January 1, 2019, to December 31, 2021, were studied. The clinical and laboratory data of fungal bloodstream infection were analyzed using Whonet 5.6 and Microsoft Excle pivot table. information. Results From January 1, 2019, to December 31, 2021, Candida accounted for 88.8%(1083/1 220) of the 1 220 fungal strains was reported by 28 hospitals. Candida albicans was the main species, accounting for 35.3%(431/1 220).and Cryptococcus neoformans being fifth in the total number of isolates, accounting for 8.3%(101/1 220). Males accounted for 56.6%(690/1 220), and female patients were less(43.4%, 530/1 220); 79.8% cases were middle-aged and elderly patients(>46 years old) and 34.8% cases were from the intensive care unit. C. albicans had the highest sensitivity to fluconazole(85.7%); resistance rates of C.tropicalis to fluconazole and voriconazole were 43.4% and 43.3%, respectively. by C. albicans isolates were dominated in Most hospitals, however, C. parapsilosis was mostly isolated in children’s specialized hospitals. Conclusion The pathogens of fungal bloodstream infection and their antifungal drug susceptibility have regional characteristics. Accurately grasping the epidemiological data in the region can provide a basis for the clinical selection of antifungal drugs.更多还原