【摘要】 目的 探讨94例念珠菌血流感染患者的临床分布特点及发生死亡的相关危险因素。方法 回顾性分析柳州市人民医院2019年1月—2021年12月确诊为念珠菌血流感染患者的临床特征及其发生死亡危险因素。结果 2019年—2021年血流感染患者共检出94例念珠菌，主要分布于ICU和外科，占58.5%;排在前三位的念珠菌分别是白念珠菌、热带念珠菌、近平滑念珠菌，分别占48.9%、16.0%、13.8%;94例念珠菌血流感染患者中死亡33例，死亡率为35.1%;死亡患者中检出最高的为白念珠菌(57.6%,19/33),主要分布于ICU(57.6%,19/33);药敏结果显示，近平滑念珠菌对唑类抗真菌药敏感率为100%,白念珠菌对三唑类药物耐药率<7%,光滑念珠菌及热带念珠菌对其耐药率为20%～26.7%;单因素分析显示年龄≥60岁、基础疾病≥2种、机械通气、气管插管与死亡率有关(P<0.05),logistic二元回归分析结果提示机械通气是与念珠菌血流感染患者死亡率相关的独立危险因素。结论 白念珠菌在念珠菌血流感染中检出率最高，机械通气是念珠菌血流感染患者发生死亡的独立危险因素。更多还原

【Abstract】 Objective To investigate the clinical distribution of 94 patients with blood flow infection of Candida and the related risk factors of death. Methods The clinical characteristics and death risk factors of patients with blood flow infection of Candida diagnosed in Liuzhou People’s Hospital from January 2019 to December 2021 were analyzed retrospectively. ResultsFrom 2019 to 2021, 94 cases of Candida were detected in blood flow infection patients, mainly distributed in ICU and surgery, accounting for 58.5%; The top three Candida species were C. albicans, C. tropicalis and C. parapsilosis, accounting for 48.9%, 16.0% and 13.8% respectively; 33 of 94 patients with blood flow infection of Candida died, the mortality rate was 35.1%. C. albicans(57.6%, 19/33) was most frequently detected in the dead patients, mainly distributed in ICU(57.6%, 19/33). The sensitivity rate of C. parapsilosis to azoles was 100%, the resistance rate of C. albicans to triazoles was less than 7% and the resistance rate of C. glabrata and C. tropicalis was 20%～26.7%. Univariate analysis showed that age ≥60 years, ≥2 basic diseases, mechanical ventilation and endotracheal intubation were associated with mortality(P<0.05). Logistic binary regression analysis showed that mechanical ventilation was an independent risk factor associated with mortality in patients with Candidal blood flow infection. Conclusion The detection rate of C. albicans in Candidal blood flow infection was the highest. Mechanical ventilation was an independent risk factor for death in patients with blood flow infection of Candida.更多还原