【摘要】 ESAT-6是结核分枝杆菌分泌的重要的毒力因子之一，参与调控巨噬细胞凋亡、自噬、炎症激活等过程。在ESAT-6的研究中，多采用有载体协助入膜的重组ESAT-6质粒或ESAT-6基因敲除/增强菌株或从大肠埃希菌中表达获得的ESAT-6重组蛋白等不同形式。因此，本文对3种形式的重组ESAT-6与巨噬细胞的相互作用进行综述，探讨其对巨噬细胞的影响有何不同，以期为结核病的诊断和疫苗开发提供理论参考。更多还原

【Abstract】 ESAT-6,one of the major virulence secretions from Mycobacterium tuberculosis,gets involved in the regulation of macrophage apoptosis, autophagy, inflammation activation, and other processes. In existing studies on ESAT-6,the recombinant plasmid ESAT-6 with vector-assisted membrane entry, ESAT-6 knockout/enhanced strains, and ESAT-6 recombinant protein generated by Escherichia coli expression were discussed.Therefore, in this paper, the interaction between three forms of recombinant ESAT-6 and macrophages was reviewed to discuss how the three forms of recombinant ESAT-6 differ in their effects on macrophages, with the aim to provide theoretical references for the diagnosis and vaccine development of tuberculosis.更多还原