【摘要】 衰老导致骨髓间充质干细胞(bone marrow mesenchymal stem cells, BM-MSCs)的分化再生、迁移归巢和免疫调节功能受损、并呈现衰老相关分泌表型(senescence-associated secretory phenotype, SASP),失去对组织的再生修复和免疫保护并诱发慢性炎症，引发年龄相关骨组织退行性病变，限制其在细胞治疗中的使用效果，提高使用风险。BM-MSCs衰老研究对预防和治疗年龄相关骨组织退行性病变及完善BM-MSCs的临床应用极其重要。该文综述了BM-MSCs衰老研究的最新进展，并提出了一些抑制BM-MSCs衰老的新策略和新思路。更多还原

【Abstract】 Senescence of bone marrow mesenchymal stem cells(BM-MSCs) result in the decreased plasticity and regeneration potential, impaired migration and homing ability, and the senescence-associated secretory phenotype(SASP), and leads to compromised tissue repair and immune protect function, as well as induced chronic inflammation, causing age-related bone tissue degeneration. Moreover, senescence reduces the effectiveness while increases the risk of BM-MSCs application in cell therapy. Therefore, research in BM-MSCs senescence is of great importance for the prevention and treatment of aging-associated bone tissue degenerative diseases, and the improvement of BM-MSCs clinical application. In this paper, the latest research progress in BM-MSCs senescence is reviewed. The new strategies and ideas to inhibit BM-MSCs senescence are also suggested.更多还原