【摘要】 目的 研究临床40周岁及以上患者骨密度与铁代谢相关指标的关系。方法 纳入广州中医药大学第一附属医院二骨科40周岁及以上的住院患者208例，分为骨量正常组（64例）、骨量减少组（92例）和骨质疏松组（52例）,测量患者的骨密度、血红蛋白、血清铁、转铁蛋白、γ-谷氨酰转肽酶等，进行各变量的组间比较及其与骨密度的相关性研究和回归分析。结果血红蛋白（P<0.001）、转铁蛋白（P=0.001）、γ-谷氨酰转肽酶（P<0.001）的组间差异具有统计学意义；血红蛋白、转铁蛋白与股骨大粗隆（r=0.493,P<0.001;r=0.243,P<0.001）及股骨干骨密度（r=0.319,P<0.001;r=0.331,P<0.001）明显相关，与L₁～L₄腰椎骨密度无明显相关；有序多元Logistic回归分析结果显示，年龄、性别、BMI、血红蛋白、转铁蛋白为骨质疏松的独立影响因素（分别为OR=1.06,P<0.001;OR=3.36,P<0.001;OR=0.82,P<0.001;OR=0.97,P=0.008;OR=0.27,P=0.021）。结论 人体内铁蓄积与骨密度水平负相关，血红蛋白、转铁蛋白及γ-谷氨酰转肽酶是骨质疏松发生的重要影响因素。更多还原

【Abstract】 Objective To study the relationship between iron and osteoporosis. Methods A total of 208 inpatients were enrolled in the second Department of Orthopedics, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine. They were divided into normal group(n=64), osteopenia group(n=92) and osteoporosis group(n=52). The BMD, hemoglobin content, serum iron, transferrin and gamma-glutamyltransferase were measured. All variables were compared between groups and their correlation with bone mineral density was studied and regression analysis was performed. Results The hemoglobin content(P<0.001), transferrin(P=0.001), γ-glutamyltranspeptidase(P<0.001) were statistically significant; Hemoglobin content, transferrin and greater trochanter of femur(r=0.493, P<0.001; r= 0.243, P<0.001) and bone mineral density(r=0.319, P<0.001; r=0.331, P<0.001) significantly correlated with L1-L4 lumbar bone mineral density; The result of ordered multiple logistic regression analysis showed that age, gender, BMI, hemoglobin content and transferrin were independent influencing factors of osteoporosis(OR=1.06, P<0.001; OR=3.36, P<0.001; OR=0.82, P<0.001; OR=0.97, P=0.008; OR=0.27, P=0.021). Conclusion Iron accumulation in human body is negatively correlated with bone mineral density. Hemoglobin, transferrin and γ-glutamyltranspeptidase are important factors affecting the occurrence of osteoporosis.更多还原