【摘要】 目的 回顾性分析单胎与多胎ROP的发病及治疗情况。方法 收集2013年1月至2015年12月广东省妇幼保健院新生儿科住院早产儿病例共4596例,使用RetCamⅡ系统进行眼底筛查,记录单胎及多胎患儿性别、胎龄、出生体重、机械通气及ROP的分期、分区、治疗等情况,使用χ~2检验和t检验进行统计分析。结果4596例早产儿中,诊断为ROP共239例,发病率为5.20%。单胎4096例,发生ROP 178例(4.35%),多胎500例,发生ROP 61例(12.20%),其中双胎60例,三胎1例,两组间比较差异有统计学意义(χ~2=55.762,P<0.001)。单胎ROP组和多胎ROP组患儿在性别、胎龄、出生体重、机械通气、急进性后极部ROP、附加病变、ROP分期、手术治疗的比较中,差异均无统计学意义(P>0.05)。然而在ROP分区的比较中,多胎组视网膜1区的病变较单胎组高[12 (19.67%),11 (6.18%)],差异有统计学意义(χ~2=9.510,P=0.009)。结论 我院ROP的发病率为5.20%,多胎ROP发病率较单胎高,且多胎ROP在视网膜1区病变较单胎高。更多还原

【Abstract】 Objective To retrospectively analyze the incidence and treatment ROP in singleton and multiparous infants.Methods A total of 4596 cases of premature infants hospitalized in the neonatal department of Guangdong Maternal and Child Health Hospital from January 2013 to December 2015 were collected.Wide-field digital fundus camera(RetCamII) system was used for fundus screening.And the sex,gestational age,birth weight,mechanical ventilation and staging,partitioning and treatment of ROP of singleton and multiparous infants were recorded,and statistical analysis was performed using X2 test and t-test.Results Among 4596 preterm infants,a total of 239 cases were diagnosed with ROP,with an incidence of 5.20%.There were 178(4.35%) cases of ROP in 4096 cases of singleton and 61(12.20%) cases of ROP in 500 cases of multiple births(60 cases of twin births and 1 case of triplet births),with statistically significant differences between the two groups(χ~2=55.762,P<0.001).There was no statistically significant difference between the singleton ROP group and the multiparous ROP group in terms of sex,gestational age,birth weight,mechanical ventilation,aggressive posterior ROP,plus disease,ROP staging,and surgical treatment(P>0.05).However,in the comparison of ROP partitions,the lesions in retinal zone 1 were higher in the multifetal group compared to the singleton group[12(19.67%) vs 11(6.18%)],and the difference was statistically significant(χ~2=9.510,P=0.009).Conclusion The prevalence of ROP in our hospital was5.20%,the prevalence of multifetal ROP was higher than singleton,and multifetal ROP had higher lesions in retinal zone 1 than singleton ROP.更多还原