【摘要】 目的 探讨微信联合电话随访在慢性阻塞性肺疾病稳定期患者吸入药物所致口咽部不良反应的应用。方法回顾性分析2021年1月至12月在中山大学附属第三医院住院并参与本院“慢阻肺之家”患教活动的120例慢性阻塞性肺疾病稳定期患者的临床资料，采用随机数字表法分为对照组（60例）与试验组（60例）。对照组于住院期间、出院时进行吸入药物的教育活动，出院后每月门诊随访，共6个月。试验组在对照组的基础上接受微信联合电话随访，随访频率为出院后前2个月每2周1次，后4个月每月1次。比较两组患者出院时、出院6个月的呼吸问卷[改良版英国医学研究委员会呼吸问卷（m MRC）、COPD患者自我评估测试问卷（CAT）、吸入药物依从性测试量表（TAI）中文版评分；随访期间，记录两组吸入药物所致口咽部不良反应如咽痛、声嘶、口干以及念珠菌感染的发生率。结果 随访前两组患者的性别、年龄、受教育程度、m MRC、CAT、TAI评分比较，差异无统计学意义（P>0.05）。出院后6个月，试验组的TAI评分高于对照组，口咽部不良反应发生率、m MRC、CAT评分均低于对照组，差异有统计学意义（P<0.05）。结论 微信+电话随访可有效降低吸入药物所致口咽部不良反应的发生率，提高并维持患者良好的吸入药物依从性，减少患者慢性阻塞性肺疾病相关呼吸系统症状。更多还原

【Abstract】 Objective To explore the application of We Chat combined with telephone follow-up in the oropharyngeal adverse reactions caused by inhaled drugs in patients with stable chronic obstructive pulmonary disease(COPD). Methods The clinical data of 120 patients with stable COPD who were hospitalized in the Third Affiliated Hospital of Sun Yat-sen University from January 2021 to December 2021 and participated in the patient education activities of“COPD home”in the hospital were retrospectively analyzed. They were divided into the control group(60 cases) and the experimental group(60 cases) according to the random number table method. The control group received inhalation education activities during hospitalization and discharge, and were followed up in the outpatient department every month after discharge, for a total of6 months. On the basis of the control group, the experimental group received We Chat combined with telephone follow-up after discharge, the frequency of follow-up was once every two weeks in the first two months, and once a month in the last four months. The scores of respiratory questionnaires such as modified British Medical Research Council(m MRC), COPD Self-Assessment test Questionnaire(CAT), the test of the adherence to inhalers(TAI) Chinese version at discharge and 6months after discharge were compared between the two groups. During follow-up, the incidence of oropharyngeal adverse reactions such as pharyngeal pain, hoarseness, dry mouth and candida infection were recorded in the two groups. Results Before follow-up, there were no significant differences in gender, age, education level, m MRC, CAT and TAI scores between the two groups(P>0.05). Six months after discharge, TAI scores of the experimental group was higher than that of the control group, and the incidence of oropharyngeal adverse reactions, m MRC and CAT scores of the experimental group were lower than those of the control group, with statistical significances(P <0.05). Conclusion We Chat combined with telephone follow-up can effectively reduce the incidence of oropharyngeal adverse reactions caused by inhaled drugs, improve and maintain patients’ good compliance with inhaled drugs, and reduce patients’ COPD related respiratory symptoms.更多还原