【摘要】 目的 探讨不同分期精神分裂症患者的血脂及肠道菌群代谢情况。方法 选取2018年11月至2019年7月泉州市第三医院的42例精神分裂症急性期患者作为急性期组,41例缓解期患者作为缓解期组,志愿招募匹配的40例健康人作为健康对照组,收集其性别、年龄、身高、体重指数、病程等一般资料,并收集血液和粪便标本,检测总胆固醇(TC)、高密度脂蛋白(HDL)、三酰甘油(TG)、载脂蛋白A1(APOA1)、载脂蛋白B1(APOB1)。采用液相色谱-质谱分析法分析菌群代谢特征并比较三组间的差异性。结果 急性期组TC、HDL、TG、APOA1、APOB1高于缓解期组,缓解期组患者上述指标高于健康对照组,差异有统计学意义(P<0.05);急性期组拟杆菌属、埃希氏杆菌属丰度高于缓解期组与健康对照组,其余指标低于缓解期组与健康对照组,差异有统计学意义(P<0.05)。结论 急性期精神分裂症患者TC、HDL、TG等血脂水平更高且肠道菌群物种分布主要为拟杆菌属、埃希氏杆菌属,与缓解期精神分裂症患者以及正常人群有一定差异。更多还原

【Abstract】 Objective To investigate the metabolism of blood lipids and intestinal flora in patients with different stages of schizophrenia. Methods From November 2018 to July 2019, 42 patients with acute stage of schizophrenia in Quanzhou Third Hospital were selected as the acute group, 41 patients with remission stage as the remission group, and 40 matched healthy people were recruited as the healthy control group. General data such as gender, age, height, body mass index and course of disease were collected. Blood and stool samples were collected to detect total cholesterol(TC), high-density lipoprotein(HDL), triglyceride(TG), apolipoprotein A1(APOA1), apolipoprotein B1(APOB1). The characteristics of bacterial metabolism were analyzed by liquid chromatography-mass spect rometry and the differences among the three groups were compared. Results TC, HDL, TG, APOA1 and APOB1 in acute group were higher than those in remission group, and the indexes in remission group were higher than those in healthy control group, the differences were statistically significant(P<0.05). The abundance of Bacteroides and Escherichia in acute group were higher than those in remission group and healthy control group, and the rest indexes were lower than those in remission group and healthy control group, the differences were statistically significant(P<0.05). Conclusion The levels of TC, HDL, TG and other blood lipids were higher in patients with acute schizophrenia, and the species distribution of intestinal flora mainly belonged to Bacteroides and Eschella, which were different from patients with schizophrenia in remission and normal population.更多还原