【摘要】 目的 分析耐甲氧西林金黄色葡萄球菌(MRSA)感染的临床分布及其耐药性，为临床医生合理使用抗菌药物提供指导依据，提高临床抗感染治疗的成功率。方法 收集2021年1月至2022年12月景德镇市第二人民医院临床科室送检微生物样本中分离的228株金黄色葡萄球菌，对样本来源、临床科室分布情况做统计分析，并采用最新美国临床和实验室标准化委员会(CLSI)推荐的最低抑菌浓度(MIC)法、纸片扩散法(K-B法)检出MRSA，分析其耐药情况。结果 228株金黄色葡萄球菌中共检出40株MRSA，检出率为17.54%。临床科室分布显示，40株MRSA主要集中在骨科(25.00%)和耳鼻喉科(25.00%)，其次为呼吸内科(12.50%)。样本来源显示，40株MRSA来源以分泌物样本最多(55.00%)，其次为痰液样本(17.50%)。耐药性显示，MRSA对青霉素、红霉素及克林霉素有明显耐药性，对环丙沙星、左氧氟沙星、莫西沙星、四环素、复方新诺明、庆大霉素部分耐药，对利福平呈现低耐药性，对替加环素、利奈唑胺、万古霉素未产生耐药。年龄≥50岁的红霉素、环丙沙星、左氧氟沙星、莫西沙星、四环素略高于年龄<50岁者。结论 景德镇市第二人民医院MRSA感染主要分布于骨科和耳鼻喉科，且对青霉素、红霉素及克林霉素产生较高耐药性，临床科室及院感科需要将该类科室患者列为重点监测对象，并合理选择敏感抗菌药物，以提高临床抗感染治疗的成功率。更多还原

【Abstract】 Objective To analyze the drug resistance and clinical distribution of Methicillin-resistant Staphylococcus aureus(MRSA) infection, provide guidance for clinicians to use antibiotics reasonably, and improve the success rate of clinical anti-infection treatment. Methods A total of 228 strains of Staphylococcus aureus isolated from the microbial samples submitted by the clinical department of the Second People’s Hospital in Jingdezhen City from January 2021 to December 2022 were collected.The sample sources and distribution of clinical departments were statistical analyzed,MRSA was detected using the latest minimum inhibitory concentration(MIC) method and Kirby-Bauer test(K-B method)recommended by the United States Committee for Clinical and Laboratory Standardization(CLSI), and its drug resistance was analyzed. Results A total of 40 MRSA strains were detected from 228 Staphylococcus aureus strains, with a detection rate of 17.54%.The distribution of clinical departments showed that 40 MRSA strains were mainly concentrated in orthopedics(25.00%) and otolaryngology(25.00%), followed by respiratory medicine(12.50%). The sample sources,secretion samples were the most common source of 40 MRSA strains(55.00%), followed by sputum samples(17.50%). The drug resistance showed that MRSA was significantly resistant to Penicillin, Erythromycin and Clindamycin, it was partially resistant to Ciprofloxacin, Levofloxacin, Moxifloxacin, Tetracycline, Trimethoprim/sulfamethoxazole and Gentamicin,low resistance to Rifampicin, there was no resistance to Tigecycline, Linezolid and Vancomycin. Erythromycin,Ciprofloxacin, Levofloxacin, Moxifloxacin and Tetracycline were slightly higher in patients aged ≥50 years than those aged<50 years. Conclusion MRSA infection in the Second People’s Hospital of Jingdezhen is mainly distributed in orthopedics and otorhinolaryngology, and has high drug resistance to Penicillin, Erythromycin and Clindamycin. Clinical departments and hospital infection departments need to list patients in these departments as key monitoring objects, and reasonably select sensitive antibiotics to improve the success rate of clinical anti-infection treatment.更多还原