【摘要】 在全球范围内，妊娠期梅毒的发病率呈上升趋势。在中国，随着降消项目的开展，先天梅毒发病率及围产儿死亡率明显下降。妊娠期梅毒感染的高危因素包括：多性伴侣、吸毒、文化程度中等、无业/待业。推荐所有孕妇在第1次就诊时采用梅毒血清学试验进行筛查，螺旋体试验和非螺旋体试验相互确诊。对螺旋体颗粒凝集试验（treponema pallidum particle agglutination assay,TPPA）阳性的孕妇予苄星青霉素240万U肌肉注射，1次/周，连续3周。梅毒感染孕产妇所分娩新生儿出生后取血筛查TPPA、甲苯胺红不加热血清试验（toluidine red unheated serum test,TRUST）及梅毒螺旋体IgM抗体，并予苄星青霉素5万U/kg肌注预防梅毒感染。更多还原

【Abstract】 The incidence of syphilis in pregnancy is on the rise globally.In China,with the implementation of the elimination programs,the incidence of congenital syphilis and perinatal mortality have decreased significantly. High-risk factors for syphilis infection during pregnancy include: multiple sexual partners,drug abuse,moderate educational level,and unemployment.It is recommended that all pregnant women be screened with a syphilis serology test at the first visit, with treponemal and non-treponemal tests mutually confirming the diagnosis. Three doses of penicillin G benzathine 2.4 million units for intramuscular injection one a week are recommended for pregnant women with positive treponema pallidum particle agglutination assay(TPPA). After birth, the blood of newborns born to syphilis-infected mothers is taken to screen for TPPA, toluidine red unheated serum test(TRUST)and treponema pallidum IgM antibodies, and penicillin G benzathine of 50 000 U/kg intramuscularly is administered for preventing syphilis infection.更多还原