【摘要】 目的 分析麻疹病毒(Measles virus, MV)IgG阳性实验室确诊麻疹病例的IgG亲和力特征。方法 选择广西2015-2017年MV IgG阳性实验室确诊麻疹病例，采用基于MV IgG酶联免疫吸附试验的尿素变性亲和力检测方法，检测血清IgG亲和力，分析平均相对亲和力指数(Relative avidity index, RAI)和高/中/低亲和力比例。结果 在136例MV IgG阳性麻疹病例中，IgG平均RAI为49.74%,高、中、低亲和力分别占47.79%、28.68%、23.53%。<8月龄、8-35月龄、3-19岁、20-39岁、≥40岁病例IgG平均RAI分别为23.61%、41.60%、60.80%、52.65%、69.49%,高亲和力比例分别为0.00%、30.77%、80.00%、50.00%、84.62%;0剂次、1剂次、≥2剂次、不详含麻疹成分疫苗(Measles containing vaccine, MCV)免疫史病例的平均RAI分别为43.43%、50.34%、65.38%、47.84%,高亲和力比例分别为36.36%、46.94%、87.50%、42.11%。结论 麻疹抗体亲和力随麻疹病例年龄或MCV免疫剂次增加而呈升高趋势；<8月龄和20-39岁病例的抗体亲和力较低或下降，有必要对年轻育龄期妇女加强接种1剂MCV。更多还原

【Abstract】 Objective To analyze avidity of IgG against measles virus(MV) from laboratory-confirmed measles cases that were IgG-positive to MV.Methods We selected IgG-positive MV from laboratory-confirmed measles cases in Guangxi from 2015 to 2017 and tested sera for IgG avidity using the urea denaturation avidity detection method based on MV IgG enzyme-linked immunosorbent assay. We analyzed average relative avidity indexes(RAI) and proportions of high, medium, and low avidity.Results Among the 136 MV IgG positive measles cases, the average IgG RAI was 49.74%, and high, medium, and low avidity cases accounted for 47.79%, 28.68%, and 23.53% of cases, respectively. Average RAIs for cases aged <8 months, 8-35 months, 3-19 years, 20-39 years, and ≥40 years were 23.61%, 41.60%, 60.80%, 52.65%, and 69.49%, with proportions for high avidity being 0.00%, 30.77%, 80.00%, 50.00%, and 84.62%. Average RAIs for cases who had received 0, 1, ≥2, and an unknown number of doses of measles containing vaccine(MCV) were 43.43%, 50.34%, 65.38%, and 47.84%, with proportions for high avidity being 36.36%, 46.94%, 87.50%, and 42.11%.Conclusions The avidity of measles antibodies among measles cases increased with increasing age and number of MCV doses administered. Avidities among cases aged <8 months and 20-39 years were low. It is necessary to give a booster dose of MCV for young women of childbearing-age.更多还原