【摘要】 目的 分析湖南省健康人群脑膜炎奈瑟菌(Neisseria meningitidis,Nm)携带率和药物敏感性。方法 2008-2021年在湖南省3个区县按年龄分层选择健康人群，采集咽拭子标本，进行Nm分离培养和药物敏感性试验，分析Nm携带率和耐药率。结果 2008-2021年湖南省健康人群Nm总携带率为2.23%(175/7 841);其中0-2岁、3-4岁、5-6岁、7-14岁、15-19岁、≥20岁分别为0.00%、0.45%、0.28%、4.04%、7.02%、1.44%;A群、B群、C群、X群、Y群、W135群、不可分群Nm分别为0.00%(0株)、1.65%(129株)、0.09%(7株)、0.00%(0株)、0.03%(2株)、0.03%(2株)、0.45%(35株)。143株Nm菌株对青霉素、氨苄西林、头孢噻肟、左氧氟沙星、环丙沙星、米诺环素、复方新诺明的总耐药率分别为1.4%、0.0%、0.0%、29.4%、25.9%、0.0%、86.0%。结论 湖南省健康人群Nm携带率以青少年较高，B群和不可分群为优势Nm血清群。建议优化脑膜炎球菌疫苗免疫程序，加强B群Nm疫苗研制和合理使用抗生素。更多还原

【Abstract】 Objective To explore carriage and antibiotic sensitivity of Neisseria meningitidis(Nm) in a healthy population of Hunan province.Methods We collected oropharyngeal swab samples from healthy subjects in three counties of Hunan from 2008 to 2021 using an age-stratified random sampling method. We isolated Nm strains and tested them for antibiotic susceptibility to determine Nm carriage rates and antibiotic resistance rates.Results The overall Nm carriage rate was 2.23%(175/7 841) between 2008 and 2021. Carriage rates for 0-2-, 3-4-, 5-6-, 7-14-15-19-, and ≥20-year-olds were 0.00%, 0.45%, 0.28%, 4.04%, 7.02%, and 1.44%, respectively. Carriage rates for A, B, C, X, Y, W135, and non-groupable serogroups of Nm were 0.00%, 1.65%(129 strains), 0.09%(7 strains), 0.00%, 0.03%(2 strains), 0.03%(2 strains), and 0.45%(35 strains). Resistance of 143 Nm strains to penicillin, ampicillin, cefotaxime, levofloxacin, ciprofloxacin, minocycline, and trimethoprim-sulfamethoxazole were 1.4%, 0.0%, 0.0%, 29.4%, 25.9%, 0.0%, and 86.0%.Conclusions Nm carriage was high among adolescents of Hunan. Serogroup B and non-groupable serogroups were predominant. We suggest optimizing immunization schedules for meningococcal vaccines, developing serogroup B meningococcal vaccine, and using antibiotics appropriately.更多还原