【摘要】 传统腹膜透析液的高浓度葡萄糖、高葡萄糖降解产物、高糖基化终产物、低pH值等生物不相容性是影响腹膜透析(peritoneal dialysis,PD)疗效、导致PD技术失败的主要原因。中性pH-低葡萄糖降解产物(glucose degradation products,GDP)透析液是一种生物相容性透析液，有研究表明中性pH-低葡萄糖降解产物对终末期肾病患者的影响优于传统腹膜透析液，特别对于长透析患者。因此，本文就中性pH-低GDP腹膜透析液对终末期肾病腹膜透析患者残余肾功能、腹膜功能、腹膜炎发生率、患者生存及技术生存、腹膜结构等方面影响的研究进展进行综述。更多还原

【Abstract】 Conventional glucose-based peritoneal dialysates with higher glucose concentrations,high glucose degradation products, advanced glycation end products and lower pH have been recognized as bio-incompatible, affecting peritoneal dialysis efficacy and leading to technique failure. pH-neutral, lowglucose degradation product dialysates are relatively biocompatible, and are thought to be superior to the conventional dialysates especially in long-term use of peritoneal dialysis. In this paper, we review the recent advances in p H-neutral, low-glucose degradation product dialysates on the residual renal function,peritoneal function, peritonitis rate, patient and technique survival, and peritoneum pathology in peritoneal dialysis patients.更多还原