【摘要】 目的 分析单发肝细胞癌最大径≤3.0cm患者射频消融术后病灶残留的影响因素。方法 选取2013年1月至2022年6月金华市人民医院收治的肝细胞癌最大径≤3.0cm的患者239例,所有患者均行射频消融术治疗,按照术后病灶是否完全消融分为完全消融组(n=219)与病灶残留组(n=20),采用单因素分析比较两组临床资料的差异,进一步采用二元Logistic回归模型分析术后病灶残留的影响因素。结果 两组的病灶位于肝段间、肝细胞分化程度、肝纤维化程度、Child-Pugh分级以及甲胎蛋白水平方面比较,差异有统计学意义(P<0.05)。二元Logistic回归模型分析结果发现,病灶位于肝段间、肝细胞分化程度、肝纤维化程度以及甲胎蛋白水平≥200μg/L是术后病灶残留的独立影响因素(P<0.05)。结论 分析单发肝细胞癌最大径≤3.0cm患者射频消融术后病灶残留的影响因素,有助于临床医生术前早期制定治疗方案,提高治疗效果。更多还原

【Abstract】 Objective To analyze the influencing factors of residual lesions after radiofrequency ablation in patients with single hepatocellular carcinoma whose maximum diameter is ≤3.0cm. Methods A total of 239 patients with hepatocellular carcinoma with a maximum diameter of ≤3.0cm admitted to the People’s Hospital of Jinhua from January 2013 to June 2022 were selected.All patients underwent radiofrequency ablation. According to whether the lesions were completely ablated after surgery, they were divided into the complete ablation group(n=219) and the residual lesion group(n=20). Univariate analysis was used to compare the differences in clinical data between the two groups, and then the binary Logistic regression model was used to analyze the influencing factors of postoperative residual lesions. Result There were statistically significant differences between the complete ablation group and the residual lesion group in terms of the location of the lesions between liver segments, the degree of hepatocyte differentiation, the degree of liver fibrosis, the Child-Pugh grade and the level of alpha-fetoprotein(P<0.05).The results of binary Logistic regression model analysis showed that the location of lesions between liver segments, the degree of hepatocyte differentiation, the degree of liver fibrosis and the level of alpha-fetoprotein ≥ 200μg/L were independent influencing factors of postoperative residual lesions(P<0.05). Conclusion To analyze the influencing factors of residual lesions after radiofrequency ablation in patients with single hepatocellular carcinoma with a maximum diameter of≤3.0cm, which will help clinicians to formulate treatment plans early before surgery and improve the treatment effect.更多还原