【摘要】 目的 研究肉果草Lancea tibetica的化学成分。方法 综合应用硅胶、Sephadex LH-20和制备液相等多种色谱方法进行分离纯化，并根据化合物NMR谱、MS谱等数据进行结构鉴定。采用斑马鱼炎症模型进行抗炎活性评价。结果 从肉果草乙醇提取物的醋酸乙酯萃取部位中分离得到1对新的四氢呋喃型木脂素苷类化合物（1a和1b）和已知化合物肉果草苷（2）。结论 化合物1a和1b为新化合物，是1对能发生差向异构的、不可分的化合物，分别命名为肉果草苷A(1a)、肉果草苷B(1b)，且具有抗炎活性。更多还原

【Abstract】 Objective To study the chemical constituents of Lancea tibetica. Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20 column chromatography and preparative RP-HPLC. Their structures were elucidated by analysis of NMR and HR-ESI-MS spectroscopic data. Zebrafish model was used to evaluate the anti-inflammatory activity of compounds. Results A pair of new tetrahydrofuran-type lignan glycosides(1a and 1b) and a known compound(tibeticoside) were isolated from the EtOAc-soluble partition of the aqueous ethanolic extract of L. tibetica. Conclusion Compounds 1a and 1b are new compounds, a pair of epimeric and indivisible compounds, named(7R,8R,8′S,9′S)-9′-hydroxyl tibeticoside and(7R,8R,8′S,9′R)-9′-hydroxyl tibeticoside, respectively. And compound 1 shows anti-inflammation activity.更多还原