【摘要】 目的 探讨甲泼尼龙治疗突发性耳聋的临床效果。方法 选取突发性耳聋患者70例，研究时间2019年11月至2020年11月。以统计学软件将患者分成两组。予以对照组（n=30）患者地塞米松治疗，予以观察组（n=40）甲泼尼龙治疗。同时将观察组按照甲泼尼龙的使用方法分成两组，其中观察组1组（n=20）采用甲泼尼龙冲击治疗方案，观察组2组（n=20）采用常规剂量治疗。对比对照组、观察组治疗疗效、血流变指标、不良反应。同时对比观察组1组、2组的治疗疗效、血流变指标及不良反应。结果 观察组治疗总有效率高于对照组（P <0.05）。观察组耳鸣等症状改善时间早于对照组（P <0.05）。治疗前两组血流变指标对比差异不显著（P> 0.05）；治疗后观察组血浆黏度、血小板聚集率、血细胞比容均低于对照组（P <0.05）。两组不良反应发生率对比，差异不显著（P> 0.05）。观察组1组、观察组2组两组治疗总有效率对比差异不显著（P> 0.05）。观察组1组耳鸣等症状缓解时间早于对照组（P <0.05）。观察组1组不良反应发生率高于观察组2组（P <0.05）。结论 甲泼尼龙在治疗突发性耳聋中效果高于地塞米松，可促进患者耳鸣等症状缓解，改善血流变指标；此外，本次研究还证实甲泼尼龙冲击治疗相较常规剂量无明显的优势，但会增加不良反应风险。更多还原

【Abstract】 Objective To explore the clinical effect of methylprednisolone in the treatment of sudden deafness. Methods 70 patients with sudden deafness were selected, and the study period was from November 2019 to November 2020. The patients were divided into two groups by statistical software. The patients in the control group(n=30) were treated with dexamethasone, and the patients in the observation group(n=40) were treated with methylprednisolone. At the same time, the observation group was divided into two groups according to the use method of methylprednisolone, in which the observation group 1(n=20) was treated with methylprednisolone pulse therapy, and the observation group 2(n=20) was treated with conventional dose. The therapeutic effect, hemorheology index and adverse reactions were compared between the control group and the observation group. At the same time, the therapeutic effect, hemorheology index and adverse reactions of group 1 and group 2 were compared. Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05). The improvement time of tinnitus and other symptoms in the observation group was earlier than that in the control group(P<0.05). There was no significant difference in hemorheology between the two groups before treatment(P>0.05);After treatment, the plasma viscosity, platelet aggregation rate and hematocrit in the observation group were lower than those in the control group(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). There was no significant difference in the total effective rate of treatment between the observation group 1 and the observation group 2(P>0.05). The remission time of tinnitus and other symptoms in the observation group 1 was earlier than that in the control group(P<0.05). The incidence of adverse reactions in the observation group 1was higher than that in the observation group 2(P<0.05). Conclusion The effect of methylprednisolone in the treatment of sudden deafness is higher than that of dexamethasone, which can promote the remission of patient tinnitus and other symptoms and improve the hemorheology index; In addition, this study also confirmed that methylprednisolone pulse therapy has no obvious advantages over common doses, but will increase the risk of adverse reactions.更多还原