【摘要】 目的 探索职业压力与男性警察血三酰甘油（triglyceride,TG）的关系，为男性警察高三酰甘油血症（hypertriglyceridemia,HTG）的预防提供依据。方法 从Dryad数据库中提取意大利一警察部队男性警察前瞻性队列研究的相关数据进行二次分析，2009至2014年的5年时间里通过要求-控制-支持（demand control support,DCS）模型评估职业压力大小，于2009年1月和2014年1月分别测量TG、高密度脂蛋白胆固醇（high density lipoprotein cholesterol,HDL-C）、空腹血糖、体质量指数、腰围。通过多元线性回归分析职业压力与TG的关系。使用阈值效应分析职业压力对TG影响的阈值。结果 该研究共纳入男性警察199名，经过5年的随访，7名确诊HTG，其中高职业压力组有6名（发病率8.45%），与中低职业压力组1名（发病率0.78%）相比，差异有统计学意义（P <0.01）；在校正年龄、失眠、吸烟、基线肥胖、基线TG、基线HDL-C后，随职业压力等级的增加，TG逐步增加的趋势具有统计学意义（趋势性检验P <0.01）。TG与工作要求评分呈正相关，与工作控制呈负相关，差异均有统计学意义（均P <0.01）。阈值效应分析显示当职业压力评分≥1.11时，职业压力每增加1,TG增加11.44 mg/dL(P <0.01)。结论 高职业压力与男性警察TG升高相关。更多还原

【Abstract】 Objective To explore the relationship between occupational stress and blood triglyceride(TG) in male policemen, and to provide a basis for the prevention of hypertriglyceridemia(HTG). Methods A secondary analysis was conducted using data from a prospective cohort study of male police officers in an Italian police force extracted from Dryad database. The Job Demand Control Support(DCS) model was used to assess occupational stress during the five years from 2009 to 2014. TG, high density lipoprotein cholesterol(HDL-C), fasting blood glucose(FBG), body mass index(BMI) and waist circumference(WC) were measured in January 2009 and January 2014. Multiple linear regression was used to analyze the relationship between occupational stress and TG. Threshold effect was used to analyze the threshold of the effect of occupational stress on TG. Results A total of 199 male policemen were included in the study. After 5 years of follow-up, 7 policemen were diagnosed with HTG,of which 6 patients(8.45%) were in the high occupational pressure group, of which 1 patient(0.78%) was in the medium and low occupational pressure groups. The difference between the high occupational pressure group and the medium and low occupational pressure groups was statistically significant(P<0.01). After adjusting for age, insomnia, smoking, baseline obesity, baseline TG, and baseline HDL-C, TG gradually increased with the increase of occupational stress level(P for trend<0.01). TG was positively correlated with job demand score and negatively correlated with job control score(all P<0.01). Threshold effect analysis showed that when occupational stress score was ≥1.11, TG increased by 11.44 mg/dL with each 1 increase in occupational stress(P<0.01). Conclusions High occupational stress is associated with elevated TG in male police officers.更多还原