【摘要】 目的 探讨优质护理干预在LEEP刀联合重组人干扰素α-2b凝胶治疗宫颈上皮内瘤变伴高危型人乳头瘤病毒感染中的应用价值。方法 选择福建省妇幼保健院2020年1月至2022年1月收治的140例宫颈上皮内瘤变伴高危型人乳头瘤病毒感染患者作为研究对象，按随机数表法分为观察组和对照组，每组70例。所有患者均给予LEEP刀宫颈锥切术联合重组α-2b干扰素凝胶治疗，对照组患者在围手术期给予常规护理干预，观察组患者在围手术期给予优质护理干预。比较两组术中手术指标、术后并发症及症状改善情况，术前及出院时采用焦虑自评量表、抑郁自评量表对患者心理状态进行评估，出院时评估患者的疾病知识知晓情况。结果观察组术中出血量明显少于对照组（P <0.05），手术时间明显短于对照组（P <0.05）。观察组出院时的焦虑自评量表评分、抑郁自评量表评分明显低于术前及对照组出院时（P<0.05）。观察组术后并发症发生率为2.86%，明显低于对照组的12.86%(P<0.05)。观察组患者出院时疾病知识知晓情况明显优于对照组（P <0.05）。结论 优质护理干预在LEEP刀联合重组人干扰素α-2b凝胶治疗宫颈上皮内瘤变伴高危型人乳头瘤病毒感染中的应用能够提高健康知识知晓率，减轻患者负性情绪，促进患者术后康复。更多还原

【Abstract】 Objective To explore the application value of high-quality nursing intervention in LEEP knife combined with recombinant human interferon α-2b gel in the treatment of cervical intraepithelial neoplasia with high-risk human papillomavirus infection. Methods A total of 70patients with cervical intraepithelial neoplasia and high-risk human papillomavirus infection who were admitted to our hospital from January 2020to January 2022 were selected as the research subjects. All patients were treated with LEEP knife cervical conization combined with recombinant α-2b Interferon gel treatment, the control group was given routine nursing intervention in the perioperative period, the observation group was given highquality nursing intervention in the perioperative period, all patients were followed up for 3 months after the operation, and the intraoperative surgical indicators, postoperative surgical indicators and postoperative complications were compared between the two groups. Complications and symptoms were improved. The anxiety self-rating scale and depression self-rating scale were used to evaluate the psychological state of the patients before and during the first follow-up. The disease knowledge was judged at the first follow-up after the operation, and a self-made compliance questionnaire was used. The patients’ diet, rehabilitation exercise, regular review, and medication compliance were investigated. Results The intraoperative blood loss in the observation group was significantly less than that in the control group(P<0.05), and the operation time was significantly shorter than that in the control group(P<0.05). The scores of anxiety self-rating scale and depression self-rating scale in the first follow-up after the observation group were significantly lower than those before the operation and the first follow-up in the control group(P<0.05). The vaginal bleeding time in the observation group was significantly shorter than that in the control group(P<0.05), and the vaginal bleeding and vaginal discharge were significantly less than those in the control group(P<0.05). The incidence of postoperative complications in the observation group was 2.86%,which was significantly lower than 12.86% in the control group, and the difference was statistically significant(P<0.05). The awareness of disease knowledge in the observation group was significantly better than that in the control group(P<0.05). The treatment compliance of the patients in the observation group after discharge was significantly better than that in the control group(P<0.05). Conclusion The application of high-quality nursing intervention in LEEP knife combined with recombinant human interferon α-2b gel in the treatment of cervical intraepithelial neoplasia with high-risk human papillomavirus infection can shorten the symptom improvement time, reduce the negative emotions of patients, and improve the awareness of health knowledge, and can improve the postoperative treatment compliance of patients, thereby promoting the recovery.更多还原