【摘要】 目的：了解国内外单克隆抗体药物的研究热点，分析可能的研究趋势。方法：以中国知网和PubMed上公开发表的单克隆抗体药物研究文献为基础数据(检索时间为1982年1月至2022年1月),运用CiteSpace工具，对2个文献数据库进行分析，得出国内外研究的热点和不同之处。结果：通过对2个数据库文献的知识图谱分析，可以看到乳腺癌、抗体偶联药物、临床试验、靶向治疗等均是国内外文献研究的热点。结论：CiteSpace的文献研究提示，单克隆抗体药物的研究正处在大幅提升期，在肿瘤、自身免疫、代谢等疾病领域显示出独特的优势和前景；我国单克隆抗体药物研究相关的发文量居世界第4位，在此研究方面占有重要的地位。更多还原

【Abstract】 OBJECTIVE: To investigate the research hotspots of monoclonal antibody drugs at home and abroad, and to analyze possible research trends. METHODS: Using the publicly available literature of monoclonal antibody drug research on CNKI and PubMed as basic data(retrieval time: Jan. 1982 to Jan. 2022), the two document databases were analyzed by using the CiteSpace tool, so as to derive the hotspots and differences of domestic and foreign research. RESULTS: The knowledge map analysis of literature in the two databases showed that breast cancer, antibody-conjugates drugs, clinical trials and targeted therapy are the hotspots of domestic and foreign literature research. CONCLUSIONS: The literature study of CiteSpace suggests that the research of monoclonal antibody drugs is in a period of substantial enhancement, which shows unique advantages and prospects in the fields of oncology, autoimmunity, metabolism and other diseases; China ranks 4th in the world in terms of the number of publications related to monoclonal antibody drug research, and occupies an important position in this research.更多还原