【摘要】 目的 探讨术前血浆纤维蛋白原(Fbg)联合炎症相关标志物与结直肠癌患者病理特征及预后的相关性。方法 回顾性分析西部战区总医院2017年1月至2019年7月确诊为结直肠癌并行根治性手术的615例患者，收集术前常规血液学检测结果，计算中性粒细胞/淋巴细胞(NLR)、血小板/淋巴细胞(PLR)及单核细胞/淋巴细胞(MLR)。根据ROC曲线计算最佳临界值，将Fbg分别与NLR、PLR及MLR联合评分(F-NLR、F-PLR、F-MLR),分析不同评分与结直肠癌患者术后病理特征及预后的相关性。结果 F-NLR评分与性别、肿瘤位置、T分期、是否神经侵犯之间差异有统计学意义(P<0.05);F-PLR评分与肿瘤位置、T分期之间差异有统计学意义(P<0.05);F-MLR评分与性别、年龄、肿瘤位置、T分期及是否神经侵犯差异有统计学意义(P<0.05)。多因素Cox回归分析显示，F-MLR评分是影响结直肠癌患者术后无病生存期(DFS)(P=0.002)及总生存期(OS)(P=0.005)的独立危险因素。结论 Fbg与炎症相关标志物联合的F-NLR、F-PLR、F-MLR评分是一个可靠的预测结直肠癌患者预后的指标，且F-MLR评分更有助于判断结直肠癌患者的预后。更多还原

【Abstract】 Objective To investigate the correlation between the preoperative plasma fibrinogen(Fbg) combined with inflammation-related markers and the pathological features and prognosis of patients with colorectal cancer(CRC).Methods A retrospective analysis of 615 patients who were diagnosed as colorectal cancer and underwent radical resection from January 2017 to July 2019 in the General Hospital of Western Theater Command of the Chinese People′s Liberation Army was performed. The routine hematological examination results were collected before operation. The ratio of neutrophils to lymphocytes(NLR), ratio of platelets to lymphocytes(PLR) and ratio of monocytes to lymphocytes(MLR) were calculated. According to the optimal cutoff value of ROC curve, scores of F-MLR, F-PLR and F-MLR were constructed by combining Fbg with NLR, PLR and MLR, respectively. The correlations between different scores and postoperative pathological features as well as prognosis of the CRC patients were analyzed.Results There were statistically significant differences between F-NLR score and gender, tumor location, T stage, and nerve invasion(P<0.05). There were statistically significant differences between F-PLR score and tumor location, and T stage(P<0.05). There were statistically significant differences between F-MLR score and gender, age, tumor location, T stage and nerve invasion(P<0.05). Multivariate Cox regression analysis showed that F-MLR score was an independent risk factor for disease-free survival(DFS)(P =0.002) and overall survival(OS)(P =0.005) in these CRC patients.Conclusions The F-NLR, F-PLR and F-MLR scores constructed by Fbg combined with inflammation-related markers is a reliable predictor to predict the prognosis of CRC patients. The F-MLR score is more helpful to judge the prognosis of CRC patients.更多还原