【摘要】 目的 分析胶质纤维酸性蛋白(GFAP)、泛素羧基末端水解酶L1(UCH-L1)、白介素-6(IL-6)在急性缺血性脑卒中(AIS)患者中的变化及与疾病程度、预后的关系。方法 将我院收治的68例AIS患者作为研究组，同期健康体检者72例作为对照组。对比不同人群GFAP、UCH-L1、IL-6水平，分析与AIS疾病程度的关系以及对预后的预测价值。结果 不同人群UCH-L1、GFAP、IL-6水平比较：研究组高于对照组，重度组>中度组>轻度组，预后不良组高于预后良好组(P<0.05);GFAP、UCH-L1、IL-6水平与NIHSS评分呈正相关(P<0.05);UCH-L1、GFAP、IL-6联合预测AIS患者预后的AUC=0.975,大于三者单独检测(P<0.05)。结论 AIS患者GFAP、UCH-L1、IL-6异常升高，三者与疾病程度呈正相关，对患者预后的预测有重要作用。更多还原

【Abstract】 Objective To analyze the changes of ubiquitin carboxyl-terminal hydrolase isozyme L1(UCH-L1), glial fibrillary acidic protein(GFAP) and interleukin-6(IL-6) in patients with acute ischemic stroke(AIS) and their correlation with disease severity and prognosis.Methods Sixty-eight AIS patients in our hospital were recruited as a research group. Another 72 normal people who underwent physical examination in our hospital during the same period were collected as a control group. Levels of GFAP, UCH-L1 and IL-6 in different populations were compared. The relationship between the changes of the three indexes and the disease degree and their predictive value for prognosis of AIS was analyzed.Results The levels of UCH-L1, GFAP and IL-6 in the research group were higher than those in the control group, the levels of the three indexes in the severe group > the moderate group > the mild group, and the levels in the poor prognosis group were higher than those in the good prognosis group(P<0.05). The level of IL-6 was positively correlated with NIHSS(P<0.05). The area under curve(AUC) of ROC curve analysis of combined UCH-L1, GFAP and IL-6 was 0.975, which was greater than that of the three alone(P<0.05).Conclusions GFAP, UCH-L1 and IL-6 are abnormally elevated in patients with AIS. The three indexes are positively correlated with the degree of the disease. The three indexes are of great use in inferring the prognosis of the patients.更多还原