【摘要】 外泌体是由各类细胞分泌的具有生物活性的脂质双层纳米级囊泡，可介导细胞信号。外泌体可携带免疫抑制分子和已知会干扰免疫细胞功能的细胞因子，其作用于靶细胞，直接或间接影响免疫细胞的发育、成熟和抗肿瘤活性，从而诱导肿瘤产生免疫抑制。胃癌细胞和免疫细胞衍生的外泌体可作为肿瘤免疫的调节剂，以通信介质的方式诱导肿瘤免疫逃逸以促进胃癌进展。本文就来自胃癌细胞和不同免疫细胞的外泌体在胃癌免疫应答调节中的研究现状和进展作一综述。更多还原

【Abstract】 Exosomes are bioactive lipid bilayer nanoscale vesicles secreted by various cells that mediate cell signaling.Exosomes can carry immunosuppressive molecules and cytokines known to interfere with the function of immune cells and act on target cells, directly or indirectly affecting the development, maturation, and antitumor activity of immune cells,thereby inducing immunosuppression of tumors. Exosomes derives from gastric cancer cells and immune cells can be used as regulators of tumor immunity to induce tumor immune escape as communication mediators to promote the progression of gastric cancer. In this review, the research status and progress of exosomes from gastric cancer cells, and different immune cells in the regulation of gastric cancer immune response are reviewed.更多还原