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三棱-莪术药对抗肿瘤临床应用及作用机制研究进展

Research progress on clinical application and mechanism of Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma against tumor

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【作者】 杜芳鱼麦侠胡博帆许鹏

【Author】 DU Fang;YU Maixia;HU Bofan;XU Peng;The First Clinical Medical College, Shaanxi University of Chinese Medicine;Department of Oncology, Shaanxi Provincial Hospital of Chinese Medicine;

【通讯作者】 许鹏;

【机构】 陕西中医药大学第一临床医学院陕西省中医医院肿瘤科

【摘要】 三棱-莪术是临床中常用行气活血化瘀的药对,在肿瘤治疗方面应用广泛。现代医家常通过三棱-莪术与软坚散结、扶正、健脾等药物相配伍而实现抗癌抑瘤的治疗目标。现代药理研究证实,三棱-莪术药对不仅能通过抑制肿瘤细胞增殖和生长、干扰细胞周期,而且还能通过调节机体免疫、抗血管生成等途径而起到抗肿瘤作用。但是目前其与免疫治疗、靶向治疗等联合研究及对两者配伍产生新物质、药理作用研究较少,期待通过本文的总结能够为该药对的进一步研究提供思路。

【Abstract】 Sparganii Rhizoma-Curcumae Rhizoma is a Chinese medicine pair commonly used in clinical medicine to promote qi and blood circulation and remove blood stasis, which is widely used in tumor treatment. Modern physicians often achieve the therapeutic goal of anti-cancer and tumor suppressive by Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma with softening hardness and dissipating mass, strengthening body resistance, and invigorating spleen.Modern pharmacological studies have proved that Chinese medicine pair of Sparganii Rhizoma-Curcumae Rhizoma can not only inhibit the proliferation and growth of tumor cells, interfere with the cell cycle, but also play an anti-tumor role by regulating the body’s immunity and anti-angiogenesis. However, at present, there are few studies on its combination with immunotherapy and targeted therapy, as well as on the generation of new substances and pharmacological effects in their compatibility. It is expected that the summary of this paper can provide ideas for further research of this Chinese medicine pair.

【基金】 陕西省重点研发计划项目(2020SF-348)
  • 【文献出处】 中国医药导报 ,China Medical Herald , 编辑部邮箱 ,2023年02期
  • 【分类号】R285
  • 【下载频次】162
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