【摘要】 目的 搜集、分析《普济方》中治疗膝骨关节痛的临床用药规律，为中药新方研发提供参考。方法 选取《普济方》中治疗膝骨关节痛的处方，运用SPSS 21.0与IBM SPSS Modeler 18.0对用药频次、药物属性（药性、药味、归经）进行统计和聚类分析。结果 筛选后共纳入136首方剂，包含种210味中药，高频药物为当归、附子、牛膝等；关联性药对以附子-牛膝、当归-牛膝出现最高，性味以温、辛居多，归经多归肝、肾、脾经，功效以活血化瘀、祛风除湿为主，常用药物可聚为7类。结论 本研究展示出《普济方》中治疗膝骨关节痛的用药规律，分析治疗膝关节疼痛的病机，为临床实践中药治疗膝骨关节痛提供参考，并为临床研发新方药奠定基础。更多还原

【Abstract】 Objective To collect and analyze the clinical medication rule of Puji Prescription in the treatment of knee joint pain, so as to provide reference for the research and development of new traditional Chinese medicine prescription. Methods The prescription of Puji Prescription for the treatment of knee joint pain was selected, and SPSS 21.0 and IBM SPSS Modeler 18.0 were used for statistical and cluster analysis of drug frequency and drug properties(drug property, drug taste,and meridian transformation). Results A total of 136 prescriptions were included after screening, including 210 kinds of traditional Chinese medicines. The high frequency drugs were angelica sinensis, aconite, achyranthes bidentata, etc. The associated drug pairs were aconitate-achyrannosa radix and angelica Radix achyrannosa radix. The sexual flavor was mainly warm and xin, and the meridian was mainly returned to the liver, kidney, and spleen meridian. The efficacy was mainly to promote blood circulation, remove blood stasis and remove wind and dampness. Conclusion This study shows the medication rule of Puji Prescription for the treatment of knee joint pain, analyzes the pathogenesis of the treatment of knee joint pain, provides a reference for the clinical practice of traditional Chinese medicine for the treatment of knee joint pain,and lays a foundation for the clinical research and development of new prescriptions.更多还原