【摘要】 肝细胞癌(HCC)是最常见的恶性肿瘤之一，因缺乏早期特异性诊断指标，患者确诊时往往已发生肝内外转移，失去最佳治疗时机，是我国第二大肿瘤致死原因。自噬是将受损的细胞器和错误折叠的蛋白质等包裹在自噬体后被溶酶体降解的过程，在调节肝脏功能稳态方面起重要作用。自噬在HCC发生进展过程中表现出抑制和促进的双重作用，并且自噬与HCC耐药性相关。综述自噬在HCC发生发展及治疗的机制和作用，旨在提高HCC的早期诊断，为HCC靶向治疗新策略提供科学依据，提高患者生存率。更多还原

【Abstract】 Hepatocellular carcinoma(HCC) is a one of the most common malignant tumor. Due to the lack of early specific diagnostic indicators, intrahepatic and extrahepatic metastasis often occur at the time of diagnosis, which leads to the loss of the best opportunity for treatment and occupies the second common cause of tumor death in China.Autophagy is the process by which damaged organelles and misfolded proteins are encapsulated in autophagosomes and degraded by lysosomes, which plays an important role in regulating homeostatic of liver function. It has been found that autophagy plays a dual role of inhibition and promotion during the carcinogenesis and progression of HCC,and autophagy is associated with drug resistance of HCC. The mechanism and role of autophagy in the pathogenesis and treatment of HCC was reviewed, aiming to improve the early diagnosis of HCC, provide scientific basis for the new targeted therapy strategy for HCC and improve the survival rate of patients.更多还原