【摘要】 目的:评价分析胼胝体及脑干纤维束总数量(number of tracts)、体素数(number of voxels)、容积(volume)、平均长度(length)及FA均值,与儿童智力运动发育迟缓之间的关系。方法:采用回顾性研究,收集2019年7月—2022年11月期间于珠海市妇幼保健院确诊的发育迟缓儿童(发育商<80) 136例作为观察组,另选取发育正常儿童147名作为对照组,按年龄分成7个年龄组,应用Siemens Avanto Dot 1.5T MR机对上述患者行DTI序列扫描,后处理统计软件将自动计算出所追踪纤维束的属性。定量分析7组不同年龄段观察组与对照组的纤维束各项均值。结果:0～<3M组组间对比:胼胝体及脑干纤维束各项均值,差异无统计学意义(P>0.05);3～<6M组组间对比:体素数及容积组间对比,差异有统计学意义(P<0.05);6～<9M组组间对比:体素数、容积、平均长度组间对比,差异有统计学意义(P <0.05);9～<12M组、18M～<2 Y组、2～3 Y组所有组间对比差异有统计学意义(P <0.05)。结论:DTI定量分析正中矢状位胼胝体及脑干总纤维束属性,相关参数对定量诊断智力运动发育迟缓的患儿具有可能性,旨在为影像诊断及评估提供一种新的量化方法。更多还原

【Abstract】 Objective To evaluate and analyze the relationship between the total number of corpus callosum and brainstem number of tracts, number of voxels,volume,average length and FA mean,and children’s mental and motor retardation. Methods A retrospective study was conducted to collect 136 children with developmental delay(developmental quotient <80) diagnosed at Zhuhai Maternal and Child Health Hospital from July 2019 to November 2022 as the observation group,and 147 children with normal development as the control group.They were divided into 7 age groups according to age,and DTI sequence scans were performed on the aforementioned patients using Siemens Avanto Dot 1.5T MR machine.The post-processing statistical software will automatically calculate the attributes of the tracked fiber bundles.Quantitative analysis of the mean values of fiber bundles in the observation and control groups of 7 different age groups.Results Comparison 0～<3M group:the mean values of corpus callosum and brainstem fiber bundles were without statistical significance(P> 0.05);Comarison 3-<6M group:the comparison between number of voxels and volume showed statistical significance(P <0.05);Comparison 6～9M group:number of voxels,volume,average length for inter group comparison,with statistical significance(P <0.05);All inter group comparisons of 9-<12M,18M-<2Y,and 2-<3Y groups were indicating statistical differences(P <0.05).Conclusion DTI quantitative analysis of the attributes of the Corpus callosum and the total fiber bundle of the brain stem in the midsagittal position,and the related parameters are possible for the quantitative diagnosis of children with mental motor retardation,aiming to provide a new quantitative method for image diagnosis and evaluation.更多还原