【摘要】 目的:探究临床、影像学及肿瘤标记物中女性浸润性肺腺癌的高危因素。方法:回顾性分析154例女性肺结节患者,根据病理分为浸润组及非浸润组,比较两组临床、影像学及肿瘤标记物等方面差异并采用二元logistic回归分析其独立危险因素及临界值。结果:浸润组与非浸润组的年龄、病灶直径、结节类型、毛刺征、分叶征、空泡征、胸膜凹陷征、CEA、CY-211差异具有统计学意义(P<0.05)。年龄、病灶直径及分叶征为女性浸润性肺腺癌的独立危险因素,年龄及病灶直径的临界值分别为52岁、10.5 mm,年龄每增长1岁、病灶直径每增加1 mm,女性发生浸润性肺癌的风险分别会增加9.2%[OR=1.092,95%CI(1.046～1.141)]、17.1%[OR=1.171,95%CI(1.039～1.319)];伴有分叶征的女性肺结节患者发生浸润性肺癌的风险是无分叶征的0.296倍[OR=0.296,95%CI(0.093～0.939)]。结论:年龄>52岁、病灶直径>10.5 mm、有分叶征的女性肺结节患者发生浸润性肺腺癌的风险更高,工作中应给予更多关注。更多还原

【Abstract】 Objective To explore the high-risk factors of female invasive lung adenocarcinoma in clinical,imaging and tumor markers.Methods 154 female patients with pulmonary nodules were retrospectively analyzed and divided into invasive and non-invasive group based on pathology.The differences in clinical,imaging and tumor markers between the two groups were compared,and independent risk factors and their critical values were analyzed using binary logistic regression.Results There were statistical differences in age,lesion diameter,nodule type,burr sign,lobulation sign,vacuolar sign,pleural depression sign,CEA and CY-211 between the invasive group and the non-invasive group(P <0.05).Age,lesion diameter and lobulation sign are independent risk factors for invasive lung adenocarcinoma in women.And the critical values of age and lesion diameter were 52 years and 10.5mm respectively.The risk of invasive lung cancer in women increases by 9.2% [OR=1.092,95% CI(1.046～1.141)] and 17.1%[OR=1.171,95% CI(1.039～1.319)],respectively,for each year of age and 1mm increase in lesion diameter.The risk of invasive lung cancer in female pulmonary nodule patients with lobulation sign is 0.296 times higher than that without lobulation sign[OR=0.296,95%CI(0.093～0.939)].Conclusion Women with lung nodules over 52 years old,lesion diameter>10.5mm and lobulated sign have a higher risk of developing invasive lung adenocarcinoma,more attention should be paid in work.更多还原